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The Syracuse Orange (3-6, 1-5 ACC) travel to Hard Rock Stadium on Saturday to face the Miami Hurricanes (6-2, 2-2 ACC) at 3:30 p.m. ET on ESPN. Miami enters as a four-touchdown favorite and for good reason, despite entering off a 26-20 overtime loss to SMU Mustangs and dropping two of their last three. The Hurricanes lead the ACC in scoring defense, allowing just 15.6 points per game, while Syracuse has looked completely out of rhythm offensively over the past five weeks. Whether it’s Luke Carney, Joe Filardi, or Rickie Collins under center, the Orange’s young quarterbacks will be under pressure all afternoon behind an overmatched offensive line. Miami’s front, led by elite pass-rushers Rueben Bain Jr. and Ahkeem Mesidor, projected by draftnik Mel Kiper Jr. as two of the top defensive ends in the upcoming NFL Draft, should control the line of scrimmage from the opening snap. On the other side of the ball, Miami’s offense isn’t as explosive as past Hurricanes teams, but it won’t need to be. Syracuse has struggled to stop the run, and the combination of Mark Fletcher Jr.’s power and Miami’s dominant offensive line gives the ‘Canes a clear path to wear the Orange down. Freshman wideout Malachi Toney could have another big day, especially working the middle of the field where Syracuse’s coverage has been soft. A year ago, Syracuse stunned Miami in a 42-38 shootout, overcoming a 21-0 deficit, but this time the Hurricanes look ready to settle the score, especially after slipping to No. 18 in the polls and inital College Football Playoff rankings. Expect Miami to pull away late and exact revenge with a dominant showing on both sides of the ball. Syracuse vs. Miami: Betting Preview Explore the interactive widget below to discover the latest spread, over/under, and moneyline odds and probabilities for the Syracuse-Miami game at Hard Rock Stadium. This prediction and best bet for Saturday’s ACC matchup between Miami and Syracuse is from Dimers.com, a dependable source for sports betting predictions. Matchup Overview Date: Saturday, November 8, 2025 Time: 3:30 PM ET Venue: Hard Rock Stadium Odds Spread: Miami favored at -28.5 Total (Over/Under): 45.5 Moneyline Odds: Syracuse +2500, Miami -5000 The odds and lines presented in this article are the best available from selected sports betting sites at the time of publication and are subject to change. Expert Prediction: Syracuse vs. Miami Dimers’ 10,000-game simulation gives Miami a 98% chance to win, with a projected final score of Miami 37, Syracuse 9. Between Miami’s relentless pass rush, led by Rueben Bain Jr. and Ahkeem Mesidor, and Syracuse’s inexperienced quarterback rotation, this one looks lopsided on paper. Expect running back Mark Fletcher Jr. to control the tempo and wideout Malachi Toney to find space across the middle for a few highlight plays. Best Bet: Syracuse +28.5 The spread is massive, and Miami hasn’t always shown the offensive explosiveness to consistently cover huge numbers. Syracuse’s defense tends to bend but not completely break early, which could help the Orange stay within four touchdowns before Miami’s depth takes over. A late cover is in play, especially if Miami shifts into clock-draining mode after building a comfortable lead or Carson Beck continues with his recent turnover issues. Conclusion: Syracuse vs. Miami Miami should roll comfortably, likely cruising to its seventh win of the season and avenging last year’s upset loss. Still, Syracuse’s scrappy effort and the Canes’ conservative late-game approach make the Orange a slight value against the spread. Expect a decisive but not disastrous result for Syracuse as Miami reasserts itself as an ACC contender.