Spurs at Mavericks predictions: odds, recent stats, trends and best bets for October 22

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The Debut of Cooper Flagg and the return of Victor Wembanyama. That alone makes you sit up and pay attention to this game as the Dallas Mavericks and the San Antonio Spurs tip off their respective seasons tonight at American Airlines Center. Flagg, the prodigy from Duke, turned into the reward for the Mavericks trading Luka Doncic to the Lakers late last season. Wembanyama is back after missing much of last season due to a blood clot in his right shoulder. Kyrie Irving (knee) remains sidelined for at least the first half of the season, but with the former Duke star and National Player of the Year in the lineup alongside Klay Thompson and Anthony Davis, the Mavs are expected to compete for a spot in the postseason. The Spurs are also expected to take a step forward this season and finally compete for at least a spot in the play-in tournament. Mitch Johnson takes over as head coach for the retired Gregg Popovich. Although he is doubtful for tonight’s game De’Aaron Fox (hamstring) along with Wembanyama and last year’s Rookie of the Year Stephon Castle should help Johnson begin his tenure as head coach with some positive results. Throw in Devin Vassell and the Spurs starting lineup will be a handful for opposing teams. We’ve got all the info and analysis you need to know ahead of the game, including the latest info on how to catch tipoff, odds courtesy of DraftKings recent team performance, player stats, and of course, our predictions, picks best bets for the game from our modeling tools and staff of experts. After 24 years, the NBA is back on NBC and Peacock, combining the nostalgia of an iconic era with the innovative future of basketball coverage. The NBA on NBC YouTube channel delivers fans must-see highlights, analysis, and exclusive and unique content. Game Details and How to watch the Spurs vs. Mavericks live Date: Wednesday, October 22, 2025 Time: 9:30PM EST Site: American Airlines Center City: Dallas, TX Network/Streaming: ESPN Rotoworld has you covered with all the latest NBA Player News for all 30 teams. Check out the feed page right here on NBC Sports for headlines, injuries and transactions where you can filter by league, team, positions and news type! Game odds for the Spurs at the Mavericks The latest odds as of Wednesday courtesy of DraftKings: Moneyline: San Antonio Spurs (+130), Dallas Mavericks (-155) Spread: Mavericks -2.5 Total: 224.5 points That gives the Mavericks an implied team point total of 112.44, and the Mavericks113.75. Be sure to check out DraftKings for all the latest game odds & player props for every matchup this week on the NBA schedule! Expected Starting Lineups Spurs G Stephon Castle (2024-25 Season: 81GP, 14.7ppg, 3.7reb/gm, 4.1ast/gm) G Dylan Harper (2024-25 Preseason: 3GP, 8.7ppg, 3.7reb/gm, 4.0ast/gm) F Harrison Barnes (2024-25 Season: 82GP, 12.3ppg, 3.8reb/gm, 1.7ast/gm) F Devin Vassell (2024-25 Season: 64GP, 16.3ppg, 4.0reb/gm, 2.9ast/gm) C Victor Wembanyama (2024-25 Season: 46GP, 24.3ppg, 11reb/gm, 3.7ast/gm) Mavericks PG D’Angelo Russell (2024-25 Season: 58GP, 12.6ppg, 2.8reb/gm, 5.1ast/gm) G Klay Thompson (2024-25 Season: 72GP, 14ppg, 3.4reb/gm, 2.0ast/gm) F Cooper Flagg (2024-25 Preseason: 4GP, 11.3ppg, 4.5reb/gm, 2.8ast/gm) F Anthony Davis (2024-25 Season: 51GP, 24.7ppg, 11.6reb/gm, 3.5ast/gm) C Dereck Lively II (2024-25 Season: 36GP, 8.7ppg, 7.5reb/gm, 2.4ast/gm) Important stats, trends and insights ahead of Spurs at Mavericks on Wednesday. Wembanyama is the first player in NBA history to record at least 2,000 points, 1,000 rebounds and 200 3-pointers in his first 100 games. San Antonio finished the preseason 5-0 for the first time since 1997-98. Dallas won 3 of the 4 games between these teams last season Rotoworld Best Bet Please bet responsibly. If you or someone you know has a gambling problem, call the National Gambling Helpline at 1-800-522-4700. Our model calculates projections around each moneyline, spread and over/under bet for every game on the NBA calendar based on data points like recent performance, head-to-head player matchups, trends information and projected game totals. Once the model is finished running, we put its projections next to the latest betting lines for the game to arrive at a relative confidence level for each wager. Here are the best bets our model is projecting for tonight’s Spurs & Mavericks game: Moneyline: NBC Sports Bet is staying away from a play on the Moneyline. Spread: NBC Sports Bet is recommending a play ATS on the Dallas Mavericks -2.5. Total: NBC Sports Bet is leaning towards a play on the Game Total UNDER 224.5. Want even more NBA best bets and predictions from our expert staff & tools? Check out the Expert NBA Predictions page from NBC Sports for money line, spread and over/under picks for every game on today’s calendar! If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our NBA Top Trends tool on NBC Sports! Follow our experts on socials to keep up with all the latest content from the staff: