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Researchers have established a link between specific gut bacteria species and coronary artery disease, the world's most common form of heart disease. The study identified 15 microbial species associated with the disease, with seven being significantly more abundant and eight significantly depleted in affected individuals. Coronary artery disease affects approximately 18 million Americans and 250 million people globally, causing nearly 20 million deaths each year. The findings build on previous research, moving beyond simply identifying bacteria to understanding their functional role in the heart-gut connection. The research suggests that some typically “friendly” gut bacteria, such as Lachnospiraceae, can have varying effects on health depending on the overall gut environment.