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The stage is set for another heavyweight showdown in the AFC as the Buffalo Bills welcome the Kansas City Chiefs to a raucous Highmark Stadium this afternoon. Few matchups in football deliver quite like Patrick Mahomes vs. Josh Allen, a duel that has come to define this era of quarterback play. Kansas City arrives as a slight 2.5-point favorite, powered by a 57% win probability from Dimers’ 10,000-game simulation model, while Buffalo looks to protect its home turf and regain momentum. Neither team sits atop its division entering Week 9, but the stakes remain high as two preseason Super Bowl favorites look to reassert their place among the AFC elite. Kickoff is scheduled for 4:25 p.m. ET, and the over/under is listed at 52.5 points. Dimers projects a 26–24 Chiefs victory, identifying Under 52.5 (-108) as the best value on the board. Expect Mahomes and Allen to once again trade highlight-reel moments, with Kansas City’s aerial precision facing off against Buffalo’s big-play balance. The air may be brisk in Orchard Park, but the intensity will be anything but cold when these two AFC powerhouses collide. Chiefs vs. Bills betting preview Utilize the interactive widget below to see the current spread, total, and moneyline betting odds and probabilities for the Chiefs-Bills matchup at Highmark Stadium. This prediction and best bet for Sunday’s NFL matchup between the Chiefs and Bills is from Dimers.com, a trusted source for sports betting predictions. Check out all the important details on today’s game, as well as the best odds sourced from the top sportsbooks in the country. Game details Key information on the Chiefs vs. Bills matchup, including where the game is and what time it kicks off. Teams: Kansas City Chiefs vs. Buffalo Bills Date: Sunday, November 2, 2025 Kickoff: 4:25 p.m. EST Location: Highmark Stadium NFL standings: Current NFL division standings NFL injuries: Check the latest updates to the official NFL injury report Odds The latest and best odds for the NFL contest between the Chiefs and Bills. Spread: Chiefs -2.5 (-105), Bills +2.5 (-115) Moneyline: Chiefs -130, Bills +112 Total: Over/Under 52.5 (-108/-108) The odds and lines presented in this article are the best available from selected sports betting sites at the time of publication and are subject to change. Expert prediction: Chiefs vs. Bills Leveraging trusted data analysis and advanced algorithms, the experts at Dimers have performed 10,000 simulations of Sunday’s Chiefs vs. Bills matchup. According to Dimers’ highly regarded predictive analytics model, the Chiefs are more likely to beat the Bills at Highmark Stadium. This prediction is based on the model giving the Chiefs a 57% chance of winning the game. Furthermore, Dimers predicts that the Bills (+2.5) have a 53% chance of covering the spread, while the 52.5-point over/under has a 54% chance of staying under. As always, these predictions and probabilities are accurate at the time of publication but are subject to change. Chiefs vs. Bills best bet Our top pick for the Chiefs vs. Bills Week 9 NFL matchup is to bet on Under 52.5 points (-108). This betting advice is formulated through detailed modeling and valuable wagering intelligence, designed to deliver you the best possible plays. Score prediction for Chiefs vs. Bills Dimers’ predicted final score for the Kansas City vs. Buffalo game on Sunday has the Chiefs winning 26-24. This expert prediction is based on each team’s average score following 10,000 game simulations, offering a glimpse into the potential outcome. NFL player props: Sunday NFL player prop bets are a common way to wager on Sunday’s game without necessarily betting on its outcome. This article features the most likely first and anytime touchdown scorers for the Chiefs and Bills, as well as projected player stats. Kansas City Chiefs First touchdown scorer predictions Rashee Rice: 9.6% probability Kareem Hunt: 8.8% probability Travis Kelce: 6.8% probability Anytime touchdown predictions Rashee Rice: 48.2% probability Kareem Hunt: 45.2% probability Travis Kelce: 37.2% probability Projected box score leaders QB passing yards: Patrick Mahomes, 276 yards Receiving yards: Rashee Rice, 78 yards Rushing yards: Kareem Hunt, 47 yards Buffalo Bills First touchdown scorer predictions James Cook: 11.1% probability Josh Allen: 6.9% probability Khalil Shakir: 5.4% probability Anytime touchdown predictions James Cook: 54.2% probability Josh Allen: 38.4% probability Khalil Shakir: 31.5% probability Projected box score leaders QB passing yards: Josh Allen, 243 yards Receiving yards: Khalil Shakir, 56 yards Rushing yards: James Cook, 77 yards NFL Week 9: Chiefs vs. Bills Get ready for Sunday’s matchup between the Chiefs and Bills in Week 9 of the NFL season at Highmark Stadium, which is scheduled to start at 4:25 p.m. EST. We emphasize that all of the NFL best bets and NFL predictions on this page are derived from 10,000 data-driven simulations of the Chiefs vs. Bills matchup, and they are accurate at the time of publication to help you make more informed choices when placing bets at online sportsbooks. It is important to gamble responsibly and seek trustworthy sources for accurate and up-to-date information when making online betting decisions.
