The NFL can feel random at times as evidenced by the Carolina Panthers’ results in 2025. After a 26-10 blowout loss in Jacksonville, the Panthers rallied from a large deficit in the fourth quarter to fall in Arizona, 27-22 in Week 2. Then they followed that up with a crushing 30-0 home win against Atlanta, who was coming off an upset win in Minnesota the week before. In Week 4, Carolina was back to its losing ways, this time in New England, who trounced the Panthers 42-13. Can the Panthers beat the Dolphins in Week 5 as 1.5-point home underdogs?
Hitting on an exact NFL score prediction could also result in a huge payday of around 100-1. How should you approach a matchup of disappointing 1-3 teams Ravens vs. Texans (-1.5) as Baltimore is expected to be without Lamar Jackson (hamstring), Jaxson Dart’s first road start in Giants vs. Saints (-1.5) or Patrick Mahomes’ Chiefs (-3.5) playing in Jacksonville on Monday Night Football, as well as every other Week 5 game? Before making any Week 5 NFL picks, be sure to see the exact NFL score predictions from SportsLine expert Eric Cohen.
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A SportsLine expert and host, Cohen is evaluating the entire Week 5 NFL slate and delivers score predictions and logic for each matchup. He finished the 2024-25 season with a 190-95 record on straight-up NFL betting picks (69%) and was profitable for bettors. He’s 44-19-1 (70%) on straight-up picks so far this season. Anyone who followed Cohen’s NFL predictions has been profitable at their favorite sports betting sites and betting apps. You can only see Cohen’s Week 5 NFL exact score predictions at SportsLine.
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Top Week 5 NFL picks
After diving into all 14 games on the NFL Week 5 schedule, Cohen likes the Chargers (-2.5, 48) to win and cover at home against the Commanders at 4:25 p.m. ET on Sunday.
“My NFC preseason Super Bowl pick sits at 2-2 and has been ravaged by injuries. While I think Jayden Daniels will play for the Commanders, is he going to be mobile enough to make a difference on the ground? I doubt it. Meanwhile, the Chargers have to be stinging after losing to the Giants despite rookie running back Omarion Hampton breaking out in a big way. He tops 100 combined yards in a Los Angeles win. Give me a same game parlay of Chargers money line, the total points over, and a Hampton touchdown in Week 5. Chargers 29, Commanders 23.” See his other Week 5 football score predictions at SportsLine.
How to make Week 5 NFL score predictions
In addition, Cohen is picking two winless teams to get their first win as underdogs on Sunday. You can see who they are at SportsLine, and use promo code CHAMPIONSHIP to get your first month at SportsLine for just $1.
