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The Indianapolis Colts didn't have to travel this week as they face the Atlanta Falcons in their building. The Falcons are travelling across the country into hostile territory amid a humbling turn to their season after a 2-2 start. The team's back is against the wall at 3-5. Will they manage to turn the tide?Of course, fantasy football managers are not invested in whether the Falcons have a great season in terms of wins and losses. Managers care about one thing: points. Here's a look at who managers should start to profit from the Week 10 contest.Colts vs. Falcons Fantasy Football Week 10 Start 'Em PicksJonathan Taylor at Tennessee Titans v Indianapolis Colts - NFL 2025 - Source: GettyDaniel Jones has been consistent, but Indianapolis' quarterback suffered his worst final production line of the season against one of the least productive defenses in the NFL in Week 9. As such, he dips just below the bar of "must start." He is an option if you don't have a choice and could do much worse looking elsewhere, but you also could do better.Otherwise, the usual suspects take priority, including Jonathan Taylor and Tyler Warren. Warren is likely on his last chance as a set-and-forget tight end option after a significant slowdown over the past two weeks. However, Taylor is still riding high.As for the Falcons, the suddenly explosive Drake London is a must-start as is running back Bijan Robinson. Michael Penix Jr. is startable, but not quite at a must-start level.Must StartsJonathan TaylorTyler WarrenMichael Penix Jr.Drake LondonBijan RobinsonColts vs. Falcons Fantasy Football Week 10 Sit 'Em PicksTyler Allgeier at Dolphins at Falcons - Source: GettyWhile there are plenty of starting options for both teams in Week 10, there are some landmines you must avoid. Avoiding depth receivers is paramount, including Darnell Mooney, Josh Downs, David Sills V, and KhaDarel Hodge.One more name to steer clear of is Tyler Allgeier. He's shown enough flashes for unsuspecting managers to pick him up or elevate him off the bench for the contest. However, Allgeier has seen his usage take a nosedive in recent weeks, tallying as few as two carries on Sunday against the New England Patriots.It appears clear that the Falcons were using Allgeier to help manage Bijan Robinson, but with the team's season potentially on the line in all practical respects against Indianapolis, it's all-in on Robinson.Neither defense qualifies as a must-start, although if you must choose one, go with the Atlanta defense, with Daniel Jones potentially hitting a multi-week slump after succumbing to the Pittsburgh Steelers.In future weeks, thanks to the Sauce Gardner trade, Indianapolis will be a must-have defense. However, with Gardner set to take his first steps with the organization on Sunday, per a Thursday Colts media report, expect some early growing pains as he settles in.Must SitsDarnell MooneyJosh DownsDavid Sills VKhaDarel HodgeTyler Allgeier
