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While Marie might not be able to take on Homelander by herself, she might stand a chance with some help from some of the other major supes. Homelander's biological father, Soldier Boy (Jensen Ackles), is going to be back out of cryosleep in "The Boys" season 5, and while he'll be primarily focused on taking out his nemesis, Billy Butcher (Karl Urban), any alliance he forges with Homelander is sure to be short-lived. Homelander's biological son on "The Boys," Ryan Butcher (Cameron Crovetti), has also shown that he has his father's powers, but he's still just a kid, which means he doesn't have the strength to stop dear old dad just yet even if he wanted to. Both could play major roles in taking down Homelander, though Marie is more likely to find help from familiar corners first. That includes Annie (Erin Moriarty), who's seemingly invited Marie and the other "Gen V" rebels to join her and the rest of the Boys in their fight against Vought and Homelander. When you add in A-Train (Jesse T. Usher), Kimiko (Karen Fukuhara), and possibly a returned/re-powered Queen Maeve (Dominique McElligott) to the mix, the Boys actually might be able to take down Homelander once and for all. The real wild card is going to be the Temp V-maddened Butcher, but we'll just have to wait until "The Boys" season 5 arrives sometime in 2026 to see what happens. "Gen V" is currently streaming on Prime Video.