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Syracuse travels to South Florida on Saturday to take on No. 18 Miami at Hard Rock Stadium. The Orange enter the 3:30 p.m. ET matchup on ESPN with a 3–6 record and a five-game losing streak, still searching for consistency on offense. Miami sits at 6–2 and is heavily favored, opening as nearly a four-touchdown favorite at home, though coming off a difficult 26-20 loss at SMU that knocked the Canes’ college football playoff hopes askew. Miami’s defense has been its calling card all season, and it wasn’t the reason it lost versus SMU. The Hurricanes rank among the Top 10 nationally in scoring defense, allowing just over 14 points per game, and have dominated against the run. Syracuse’s offense, plagued by protection issues and limited production on the ground, faces one of its toughest challenges of the season. Miami will be without a few starters due to injury, which could create small openings for the Orange to exploit, but the margin for error remains slim. Syracuse will try to channel some of the upset energy from last year’s stunning 42–38 win over Miami after trailing 21–0. Replicating that performance on the road will be difficult against a physical Miami squad. For the Hurricanes, this game offers a chance to reset and build momentum heading into the final stretch, while Syracuse looks to play spoiler and finish the season on a competitive note. Syracuse vs. Miami: Early Look Betting Preview Explore the interactive widget below to discover the latest spread, over/under, and moneyline odds and probabilities for the Hurricanes-Orange game at Hard Rock Stadium. This prediction and best bet for Saturday’s ACC matchup between Miami and Syracuse is from Dimers.com, a dependable source for sports betting predictions. Matchup Overview Date: Saturday, November 8, 2025 Time: 3:30 PM ET Venue: Hard Rock Stadium Odds Spread: Miami favored at -28.5 Total (Over/Under): 45.5 Moneyline Odds: Syracuse +3000, Miami -6502 The odds and lines presented in this article are the best available from selected sports betting sites at the time of publication and are subject to change. Expert Prediction Miami enters Saturday’s matchup as a heavy favorite, with Dimers’ simulations giving the Hurricanes a 98% win probability. After 10,000 simulations, the projected final score sits at Miami 37, Syracuse 9, suggesting a comfortable home victory for the No. 18 Hurricanes. Best Bet: Syracuse +28.5 (-110) While Miami’s overall edge is clear, Syracuse’s ability to hang within four touchdowns makes the spread appealing. The Orange have shown enough defensive grit to slow games down, and Miami’s recent injuries could limit its offensive rhythm. With a line sitting at nearly 29 points, Syracuse offers value against the spread in what could be a lower-scoring game than expected. Conclusion: Syracuse vs. Miami Miami should handle business at Hard Rock Stadium, using its defensive strength and home-field advantage to control the game from the start. Syracuse will need near-perfect execution to stay competitive, but if the Orange limit turnovers and find any offensive rhythm, they can cover the large spread. Expect Miami to win, though Syracuse could finish inside the number.
