Sunday in Foxboro, Drake Maye and the Patriots (1-1) host Aaron Rodgers and the Steelers (1-1).
After losing their opener to Vegas, the Pats got Head Coach Mike Vrabel his first win as New England’s leader last weekend in Miami with a 33-27 win over the Dolphins. Maye, the second-year signal-caller threw for two scores and ran for a third as New England rallied from behind in the fourth quarter to claim victory.
After a thrilling win Week 1 at the Jets, Rodgers and co. blew a halftime lead this past Sunday and lost to the Seahawks, 31-17. The comeback was aided by a botched kickoff reception by Kaleb Johnson with Seattle leading 17-14 early in the fourth quarter. The rookie walked away from a live ball and George Holani pounced on it to give the Seahawks a 24-14 lead. Quite possibly bigger than that miscue was Pittsburgh’s inability to run the ball. The Steelers gained just 72 yards on the afternoon.
Lets take a deeper dive into this Sunday’s matchup between the Steelers and the Patriots.
NBC Sports has all the latest info and analysis you need, including how to tune in for kickoff, odds from DraftKings, player news and updates, and of course our predictions and best bets for the game from our staff of experts.
Game Details and How to watch the Pittsburgh Steelers at the New England Patriots live Sunday
Date: Sunday, September 21, 2025
Time: 1:00PM EST
Site: Gillette Stadium
City: Foxborough, MA
Network/Streaming: CBS
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Game odds for the Steelers vs the Patriots
The latest odds as of Sunday courtesy of DraftKings:
Moneyline: Steelers (-122), Patriots (+102)
Spread: Steelers -1.5
Total: 44.5 points
This game opened Steelers -1.0 with the Game Total set at 42.5.
Be sure to check out DraftKings for all the latest game odds & player props for every matchup this week on the NFL schedule!
Quarterback Matchup for Pittsburgh at New England
Steelers Starting QB: Aaron Rodgers
Last Game: 9/14 vs. Seattle – 18-33 (54.6%), 203yds, 1 TD, 2 INTs, Sacked 3 times, 1 carry for 3yds
Season: 2GP, 40-63 (63.5%), 447yds, 5 TDs, 2 INTs, Sacked 7 times, 2 carries for 2yds
Patriots Starting QB: Drake Maye
Last Game: 9/14 at Miami – 19-23 (82.6%), 230yds, 2 TDs, 0 INTs, Sacked 3 times, 14 carries for 42yds
Season: 2GP, 49-69 (71%), 506yds, 3 TDs, 1 INT, Sacked 7 times, 14 carries for 42yds
Pittsburgh Steelers at New England Patriots team stats, betting trends
The Patriots are on a 3-game win streak at home to the Steelers
The Steelers are 1-4 against the spread in their last 5 games on the road
The Under is 4-1 in the Steelers’ last 5 matchups against AFC teams
Steelers Player Injuries
DT Derrick Harmon (undisclosed) is listed as questionable for Sunday’s game
LB Alex Highsmith (undisclosed) is listed as questionable for Sunday’s game
S Deshon Eilliott (undisclosed) is listed as questionable for Sunday’s game
CB Joey Porter, Jr. (undisclosed) is listed as questionable for Sunday’s game
DT Isaiahh Loudermilk (undisclosed) is listed as questionable for Sunday’s game
Patriots Player Injuries
OT Morgan Moses (lower body) is listed as questionable for Sunday’s game
CB Christian Gonzalez (undisclosed) is listed as questionable for Sunday’s game
DE Keion White (undisclosed) is listed as questionable for Sunday’s game
Rotoworld Bet Best Bets
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Our model calculates projections around each moneyline, spread and over/under bet for every game on the NFL calendar based on data points like past performance, player matchups, stadium information and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Best bets our model is projecting for this week’s game between the Steelers and the Patriots:
Moneyline: NBC Sports Bet is staying away from a play on the Moneyline.
Spread: NBC Sports Bet is leaning towards a play ATS on the New England Patriots at +1.
Total: NBC Sports Bet is staying away from a play on the Game Total of 44.0.
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