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The San Francisco 49ers will make the trip to MetLife Stadium to face off against the New York Giants. The 49ers are 5-3 this season, and are fresh off a loss to the Houston Texans in the most recent game.The New York Giants are 2-6, and they're currently on a two-game losing streak. Let's examine the details, odds, picks, and prediction for the Week 9 showdown.San Francisco 49ers vs. New York Giants: Game DetailsHere's what you need to know about watching the 49ers vs. Giants Week 9 game:Date: Sunday, November 2, 2025Livestream: FuboTV and DAZNTime: 1 p.m. ETTV Channel: CBSVenue: MetLife Stadium, East Rutherford, New JerseySan Francisco 49ers vs. New York Giants Betting Odds (via BET MGM)Here are the betting odds for the 49ers vs. Giants game according to Bet MGM:Spread49ers: +49 -118Giants: +2.5 -102Total (O/U)49ers: 48.5 -110Giants: 48.5 -110Moneyline49ers: -155Giants: 130San Francisco 49ers vs. New York Giants: PicksThe San Francisco 49ers enter Week 9 with a couple of injury issues, but their depth should enable them to field a decent lineup. However, the same can't be said about the New York Giants.The Giants have been rocked by injuries to their best wide receiver (Malik Nabers) and star rookie running back (Cam Skattebo). These injuries will undoubtedly play a part in Sunday's game, giving the visiting 49ers the edge.The 49ers have the better roster, and they're firmly in the playoff race. So the pick for this game is: 49ers -2.5; Over 48.5.San Francisco 49ers vs. New York Giants: Prediction for Week 9The Kyle Shanahan-coached San Francisco 49ers are one of the NFC's best teams when they're fully fit. However, the roster has dealt with injuries all season long, and they'll likely field a banged-up roster in their showdown with the New York Giants.Brian Daboll's New York Giants showed promise earlier this season, and Jaxson Dart's synergy with Cam Skattebo made for a noteworthy storyline. However, Skattebo's season-ending ankle injury has seemingly knocked the wind out of the side's sails.The Giants are firm underdogs in their matchup against the 49ers. Kyle Shanahan's side is just too stacked, and they have way more to play for as the season reaches its business end. So, the prediction is that the San Francisco 49ers beat the New York Giants by 15+ points at MetLife Stadium.
