Still in search of their first win this season, the New Orleans Saints (0-3) travel to Orchard Park Sunday for a date against the Buffalo Bills (3-0).
Josh Allen and co. have been sitting at home since their 31-21 win Thursday night against Miami. The Dolphins hung around for three quarters but ultimately could not take out the AFC East leaders. Allen tossed three touchdown passes and completed passes to nine different receivers as the Bills stayed perfect on the young season.
Perfect is not a term associated with the Saints this season. They have been outscored 90-47 through three games. Only three teams have put up fewer points (Houston, Cleveland, and Atlanta). To make matters worse, only five teams have allowed more (Chicago, Dallas, Miami, Jets, and Bengals)…and staring across the line of scrimmage at them Sunday are the undefeated Bills.
Lets dive deeper into this matchup between New Orleans and Buffalo.
NBC Sports has all the latest info and analysis you need, including how to tune in for kickoff, odds from DraftKings, player news and updates, and of course our predictions and best bets for the game from our staff of experts.
Game Details and How to watch the New Orleans Saints at the Buffalo Bills live Sunday
Date: Sunday, September 28, 2025
Time: 1:00PM EST
Site: Highmark Stadium
City: Orchard Park, NY
Network/Streaming: CBS
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Game odds for the Saints vs the Bills
The latest odds as of Tuesday courtesy of DraftKings:
Moneyline: New Orleans Saints (+950), Buffalo Bills (-1650)
Spread: Bills -16.5
Total: 48.5 points
This game opened at Bills -14.5 with the Game Total set at 48.50.
Be sure to check out DraftKings for all the latest game odds & player props for every matchup this week on the NFL schedule!
Quarterback Matchup for New Orleans at Buffalo
Saints Expected Starting QB: Spencer Rattler
Last game: 9/21 at Seattle – 28-39 (71.8%), 218yds, 1 TD, 1 INT, Sacked 2 times, 2 carries for 10yds
Season: 3GP, 80-119 (67.2%), 639yds, 4 TDs, 1 INT, Sacked 6 times, 10 carries for 53yds
Bills Expected Starting QB: Josh Allen
Last Game: 9/18 vs. Miami – 22-28 (78.6%), 213yds, 3 TDs, 0 INTs, Sacked 2 times, 4 carries for 25yds
Season: 3GP, 69-99 (69.7%), 755yds, 5 TDs, 0 INTs, Sacked 4 times, 24 carries for 114yds
Saints at Bills team stats, betting trends
The Bills have won 17 of their last 20 home games
The Saints are 1-4 against the spread in their last 5 road games
The Under is 4-1 in the Saints’ last 5 games
Josh Allen has yet to throw an interception this season
Saints Player Injuries
OT Taliese Fuaga (undisclosed) is listed as questionable for Sunday’s game
LB Chase Young (undisclosed) is listed as questionable for Sunday’s game
WR DeVaughn Vele (undisclosed) is listed as questionable for Sunday’s game
WR Trey Palmer (undisclosed) is listed as questionable for Sunday’s game
OT Dillon Radunz (undisclosed) is listed as questionable for Sunday’s game
Bills Player Injuries
DT Ed Oliver (undisclosed) is listed as questionable for Sunday’s game
LB Matt Milano (undisclosed) is listed as questionable for Sunday’s game
Rotoworld Bet Best Bets
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Our model calculates projections around each moneyline, spread and over/under bet for every game on the NFL calendar based on data points like past performance, player matchups, stadium information and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Best bets our model is projecting for this week’s game between the Saints and the Bills:
Moneyline: NBC Sports Bet is staying away from a play on the Moneyline.
Spread: NBC Sports Bet is leaning towards a play ATS on the New Orleans Saints at +16.5.
Total: NBC Sports Bet is recommending a play on the under on the Game Total of 47.0.
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