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Packers at Browns prediction: Odds, expert picks, QBs, injury update, betting trends, and stats

Packers at Browns prediction: Odds, expert picks, QBs, injury update, betting trends, and stats

It is a small sample size but Micah Parsons and the Green Bay Packers (2-0) appear to be among the elite in the NFL in 2025. That perfect mark will get tested on the road this weekend in Cleveland against Joe Flacco and the Browns (0-2).
After a competitive game to open the season – a 17-16 loss at home to Cincinnati – the Browns were waxed in Week 2 by the Lamar Jackson and the Baltimore Ravens, 41-17. The issues revolve primarily around the offense for Cleveland. The Browns are averaging just 82 yards rushing per game and more importantly just two touchdowns per game. Not sure how that changes but improvement is needed.
The Packers have to be feeling pretty good two weeks into the campaign. In knocking off the Lions and the Commanders, Green Bay has wins over fellow NFC contenders which could loom large in terms of playoff seeding and home field advantage. The scary part for the rest of the NFC? Jordan Love’s numbers are somewhat pedestrian. The exception is he has yet to throw an interception.
Can Cleveland’s defense force an interception or turnover of any kind and in the process keep the Browns in the game against the Pack? Lets take a deeper dive into this Week 3 matchup between the Packers and the Browns.
NBC Sports has all the latest info and analysis you need, including how to tune in for kickoff, odds from DraftKings, player news and updates, and of course our predictions and best bets for the game from our staff of experts.
Game Details and How to watch the Green Bay Packers at the Cleveland Browns live Sunday
Date: Sunday, September 21, 2025
Time: 1:00PM EST
Site: Huntington Bank Field
City: Cleveland, OH
Network/Streaming: FOX
Want to check out the other games on the NFL schedule this week? We’ve got you covered right here on NBC Sports with all the matchup, venue, game-time and TV/streaming info so you won’t miss any of the action!
Game odds for the Packers at the Browns
The latest odds as of Sunday courtesy of DraftKings:
Moneyline: Green Bay Packers (-500), Cleveland Browns (+380)
Spread: Packers -8.5
Total: 42.5 points
This game opened at Packers -6.5 with the Game Total set at 43.0.
Be sure to check out DraftKings for all the latest game odds & player props for every matchup this week on the NFL schedule!
Quarterback Matchup for Green Bay at Cleveland
Packers Starting QB: Jordan Love
Last Game: 9/11 vs. Washington – 19-31 (61.3%), 292yds, 2 TDs, 0 INTs, Sacked 2 times, 3 carries for 12yds
Season: 2GP, 35-53 (66%), 480yds, 4 TDs, 0 INTs, Sacked 2 times, 6 carries for 16yds
Browns Starting QB: Joe Flacco
Last Game: 9/14 at Baltimore – 25-45 (55.6%), 199yds, 1 TD, 1 INT, Sacked 2 times, 1 carry for 8 yards
Season: 2GP, 56-90 (62.2%), 489yds, 2 TDs, 3 INTs, Sacked 4 times, 3 carries for 14yds
Green Bay Packers at Cleveland Browns team stats, betting trends
The Packers have won 4 of their last 5 games against AFC North teams
The Browns failed to cover the spread 6 times at home last season
The Under was 19-15-1 for the Packers’ and the Browns’ games combined last season
Packers Player Injuries
LG Aaron Banks (undisclosed) is listed as questionable for Sunday’s game
RT Zach Tom (undisclosed) is listed as questionable for Sunday’s game
WR Christian Watson (knee) has been declared out of Sunday’s game
S Zayne Anderson (undisclosed) is listed as questionable for Sunday’s game
WR Jayden Reed (collarbone) has been declared out of Sunday’s game
Browns Player Injuries
RT Jack Conklin (undisclosed) is listed as questionable for Sunday’s game
WR DeAndre Carter (concussion) is listed as questionable for Sunday’s game
DT Mike Hall Jr. (undisclosed) is listed as questionable for Sunday’s game
Rotoworld Bet Best Bets
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Our model calculates projections around each moneyline, spread and over/under bet for every game on the NFL calendar based on data points like past performance, player matchups, stadium information and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Best bets our model is projecting for this week’s game between the Packers and the Browns:
Moneyline: NBC Sports Bet is staying away from a play on the Moneyline.
Spread: NBC Sports Bet is leaning towards a play ATS on the Cleveland Browns at +8.5.
Total: NBC Sports Bet is recommending a play on the over on the Game Total of 42.0.
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