By Geoff Clark

Copyright outkick

Thanks to these apps, sports betting is a 24/7 business nowadays. The NFL Week 4 market is already buzzing. From Thursday’s divisional clash to the Sunday morning kickoff in Dublin, Ireland, and all the way through Monday Night Football, which has two games this week, here’s an early look at spreads, totals, and moneylines for every matchup on the schedule. NFL Week 4 Opening Lines The odds are courtesy of DraftKings as of 2:20 a.m. ET Sunday, September 22. Thursday Night Football Seattle Seahawks (2-1) at Arizona Cardinals (2-1) Dublin, Ireland (9:30 a.m. ET, Sunday) Minnesota Vikings (2-1) vs. Pittsburgh Steelers (2-1) Sunday, 1 p.m. ET (seven games) New Orleans Saints (0-3) at Buffalo Bills (3-0) Philadelphia Eagles (3-0) at Tampa Bay Buccaneers (3-0) Cleveland Browns (1-2) at Detroit Lions (1-1)* *The Lions still have to play the Baltimore Ravens on Monday Night Football in NFL Week 3. Tennessee Titans (0-3) at Houston Texans (0-3) Washington Commanders (2-1) at Atlanta Falcons (1-2) Los Angeles Chargers (3-0) at New York Giants (0-3) Carolina Panthers (1-2) at New England Patriots (1-2) Sunday, 4 p.m. ET (four games) Indianapolis Colts (3-0) at Los Angeles Rams (2-1) Jacksonville Jaguars (2-1) at San Francisco 49ers (3-0) Baltimore Ravens (1-1)** at Kansas City Chiefs (1-2) Chicago Bears (1-2) at Las Vegas Raiders (1-2) Baltimore still has to play Detroit on Monday Night Football in NFL Week 3. Sunday Night Football Green Bay Packers (2-1) at Dallas Cowboys (2-1) Monday Night Football (two games) New York Jets (0-3) at Miami Dolphins (3-0) Cincinnati Bengals (2-1) at Denver Broncos (1-2) _____________________________ Follow me on X (or Twitter, whatever) @Geoffery-Clark, and check out my OutKick Bets Podcast for more betting content and random rants. Track my NFL 2025-26 bets here.