Coming up with a winning NFL DFS strategy can go in many different directions, but a popular one is targeting games with the highest project point totals when searching for NFL DFS picks and building NFL DFS stacks. The highest over/under in the NFL odds for Sunday is 49.5 in the Lions vs. Bengals matchup. Other potential high-scoring matchups on Sunday include Raiders vs. Colts, Cowboys vs. Jets, and Patriots vs. Bills. Thus, you can expect stars like Jahmyr Gibbs, Jonathan Taylor, George Pickens, Josh Allen, and James Cook to be core players in many NFL DFS lineups.
Players of that caliber, however, will set back your NFL DFS salary cap, forcing you to search for more potential NFL DFS sleepers and NFL DFS values. Should players like Jaxson Dart or Jake Browning find their way into your quarterback slot for Sunday’s main slate? Will underperforming players like Ja’Marr Chase and C.J. Stroud finally live up to their price tags on NFL DFS sites? Before making any NFL DFS picks for Sunday or locking in NFL DFS lineups on sites like DraftKings and FanDuel, be sure to check out SportsLine’s advanced NFL DFS lineup optimizer.
New users can also target the latest Underdog promo code, which may include a play $5, get $100 offer:
The DFS Optimizer uses info from the SportsLine Advanced-Data Projection Model and DFS Professional Millionaire Mike McClure to identify top DFS picks/plays for any slate on betting apps like DraftKings and FanDuel. It simulates every game 10,000 times to help DFS players optimize and build winning DraftKings and FanDuel lineups. Optimize, export, and enter lineups confidently with injury updates, floor and ceiling player projections, and Vegas lines and picks all with one winning tool for sports betting apps.
Now, SportsLine’s NFL DFS Optimizer has turned its attention to Sunday’s 2025 NFL Week 4 schedule and just locked in its top daily Fantasy football lineups. You can only see its optimal lineups at SportsLine.
New users can get $50 in Pick6 credits at DraftKings when they play $5.
Top NFL Week 5 DFS picks for Sunday
One of the optimizer’s top DFS value picks for Sunday is Colts quarterback Daniel Jones ($5,800 on DraftKings and $7,400 on FanDuel), who has an over/under of 231.5 passing yards. The former first-round pick out of Duke has gotten off to a strong start in 2025, throwing for 1,078 yards, four touchdowns and two interceptions through his first four games, while also tallying three rushing scores, putting him among the more efficient signal-callers in the league thus far.
In CBS Sports’ early fantasy rankings, Jones sits in the QB3–QB4 range thanks to his low turnover rate and rushing upside. With his move to Indianapolis this season, it appears he’s revived momentum and is positioning himself as both a reliable fantasy QB and a legitimate leader for the Colts’ offense. See who else to pick here.
The optimizer’s NFL DFS strategy also includes rostering Giants running back Cam Skattebo ($6,000 on DraftKings and $6,200 on FanDuel). The former Arizona State standout has shown flashes of brilliance as a rookie in 2025, rushing 48 times for 181 yards (3.8 average) and scoring two touchdowns. In CBS Sports’ fantasy football analysis, he’s received buzz as a potential fantasy breakout player — especially with the expectation that he’ll assume lead back duties.
At Arizona State and Sacramento State, he compiled 4,386 rushing yards on 709 carries with 43 touchdowns, caught 112 passes for 1,386 yards and eight receiving touchdowns, and even attempted 17 passes — showcasing his multi-dimensional skill set. As a draft prospect, he was known for his toughness and ability to break tackles. He’s already earned multiple Pepsi Rookie of the Week nominations in his first NFL season. You can see the rest of the optimizer’s NFL DFS picks here.
How to build Sunday Week 5 NFL DFS lineups
The NFL DFS Optimizer is also targeting multiple undervalued players who could explode for huge numbers on Sunday. Those players could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who they are, and the rest of the optimizer’s NFL DFS picks, at SportsLine.