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Ruben Amorim has been dealt an injury blow ahead of Manchester United’s Premier League match against Tottenham. According to The Athletic, Kobbie Mainoo has been ruled out of the trip to north London with a minor knock, and it set to be replaced in the matchday squad by youngster Jack Fletcher. Meanwhile, Lisandro Martinez, who is back in full training after making a recovery from the ACL injury he suffered in the home loss to Crystal Palace at the beginning of the year, has not been spotted with the squad in the capital. Amorim did not consider the Argentine for selection against Nottingham Forest last weekend, insisting the central defender needed more time before being ready for a return to action. "He (Martinez) wants to go to this one [Forest], he isn't going to this one,” Amorim told reporters ahead of the game at the City Ground. “He's going to need time. He has started training with us. Slowly he is going to get better.” Despite a further full week’s worth of training under his belt, it would appear that Martinez will not make his Man United return until after the international break. Harry Maguire, however, may be in contention to start as one of the three central defenders to help combat Tottenham’s set-piece strengths as well as posing a threat of his own in the opposition box. The 32-year-old missed the win over Brighton but was an unused substitute in the draw with Forest. Elsewhere, Amorim is expected to keep faith in goalkeeper Senne Lammens, while Casemiro and Bruno Fernandes should continue as the midfield double pivot. There could be a change in attack with the Portuguese tactician reverting to the system that worked wonders in the win over Liverpool at Anfield recently by playing without a recognised centre-forward. Matheus Cunha could operate as a false nine instead of Benjamin Sesko as the target man, with Bryan Mbeumo and Mason Mount as the dual No10’s. Predicted Manchester United XI: Lammens; De Ligt, Maguire, Shaw; Amad, Casemiro, Fernandes, Dalot; Mbeumo, Cunha, Mount. Injured: Mainoo Doubts: Martinez Time and date: 12.30pm GMT today, Saturday November 8, 2025 How to watch: TNT Sports Venue: Tottenham Hotspur Stadium