Sunday in Music City USA Cam Ward and the Tennessee Titans (0-2) will be looking for their first win when they take the field against Daniel Jones and the Indianapolis Colts (2-0).
A longshot to win the AFC South when the season started, the Titans will truly be behind the 8-ball with a loss to the Colts Sunday. Cam Ward has not turned the ball over this season but has thrown for an average of just 143.5yds/gm and a mere 4.7yds/attempt. He has also been sacked 11 times through two games.
The Colts are one of the early season surprise stories in the NFL having won a pair of home games against the Dolphins to open the season and then last weekend against the Broncos. If voting were to be held today, the NFL’s Comeback Player of the Year may well be Daniel Jones. The Giants’ castoff has thrown for 588 yards without tossing an interception.
Lets take a deeper dive into this Week 3 matchup between the undefeated Indianapolis Colts and the winless Tennessee Titans.
NBC Sports has all the latest info and analysis you need, including how to tune in for kickoff, odds from DraftKings, player news and updates, and of course our predictions and best bets for the game from our staff of experts.
Game Details and How to watch the Colts at Titans live Sunday
Date: Sunday, September 21, 2025
Time: 1:00PM EST
Site: Nissan Stadium
City: Nashville, TN
Network/Streaming: CBS
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Game odds for the Colts at the Titans
The latest odds as of Tuesday courtesy of DraftKings:
Moneyline: Colts (-185), Titans (+154)
Spread: Colts -3.5
Total: 43.5 points
This game opened at Colts -2.5 with the Game Total set at 42.5.
Be sure to check out DraftKings for all the latest game odds & player props for every matchup this week on the NFL schedule!
Quarterback Matchup for Indianapolis at Tennessee
Colts Starting QB: Daniel Jones
Last Game: 9/14 vs. Denver – 23-34 (67.7%), 316yds, 1 TD, 0 INTs, Sacked 1 times, 6 carries for 2yds
Season: 2GP, 45-63 (71.4%), 588yds, 2 TDs, 0 INTs, Sacked 2 times, 13 carries for 28yds
Titans Starting QB: Cam Ward
Last Game: 9/14 vs. LA Rams – 19-33 (57.6%) 175yds, 1 TD, 0 INTs, Sacked 5 times, 4 carries for 8yds
Season: 2GP, 31-61 (50.8%), 1 TD, 0 INTs, Sacked 11 times, 4 carries for 8yds
Indianapolis Colts at Tennessee Titans team stats, betting trends
The Colts have covered the Spread in 4 of their last 5 matchups against AFC South opponents
6 of the Colts’ last 8 games (75%) have gone over the Total
RB Jonathan Taylor has yet to score a TD this season
QB Daniel Jones has thrown for 2 TDs and rushed for 3
QB Cam Ward has yet to throw an interception this season
Colts Player Injuries
DE Laiatu Latu (undisclosed) is listed as questionable for Sunday’s game
CB Charvarious Ward (undisclosed) is listed as questionable for Sunday’s game
Titans Player Injuries
G Kevin Zeitler (elbow) is listed as questionable for Sunday’s game
OT JC Latham (undisclosed) is listed as questionable for Sunday’s game
WR Bryce Oliver (knee) is listed as questionable for Sunday’s game
DT T’Vondre Sweat (undisclosed) is listed as questionable for Sunday’s game
S Kevin Winston Jr. (undisclosed) is listed as questionable for Sunday’s game
Rotoworld Bet Best Bets
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Our model calculates projections around each moneyline, spread and over/under bet for every game on the NFL calendar based on data points like past performance, player matchups, stadium information and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Best bets our model is projecting for this week’s game between the Colts and the Titans:
Moneyline: NBC Sports Bet is staying away from a play on the Moneyline.
Spread: NBC Sports Bet is leaning towards a play ATS on the Tennessee Titans at +3.5.
Total: NBC Sports Bet is leaning towards a play on the under on the Game Total of 43.0.
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