The Week 5 NFL schedule kicks off on Thursday Night Football when the Los Angeles Rams host the San Francisco 49ers in an NFC West showdown. Los Angeles is now a 7-point favorite, according to the Week 5 NFL odds, after opening at -1.5. 49ers quarterback Brock Purdy (toe) and wide receiver Ricky Pearsall (knee) are listed as questionable. There are 12 games on Sunday, including matchups like Jets (+2.5) vs. Cowboys, Eagles (-4.5) vs. Broncos, Seahawks (-3) vs. Buccaneers and Chargers (-2.5) vs. Commanders. The Week 5 slate concludes with Jaguars (+3) vs. Chiefs on Monday Night Football.
Bettors looking for sportsbook promos, betting sites, and where to bet on the NFL for Week 5 can read more below, along with picks for some of the biggest games.
Sportsbook offers
Here are the top sportsbook promos for new users ahead of the 2025 Week 5 NFL schedule.
Brand
Promo
Promo Code
DraftKings
Bet $5, get $200 in bonus bets if your bet wins
Just click here
bet365
Bet $5, get $200 in bonus bets instantly
Just click here
BetMGM
Up to $1,500 in bonus bets if your first bet loses
CBSSPORTS
Caesars
Bet $1, double your winnings your next 20 bets
CBS20X
FanDuel
Bet $5, get $300 in bonus bets if your bet wins
Just click here
Fanatics
Get $100 in FanCash, plus a $100 No Sweat Bet in FanCash on every Game Day
Just click here
The DraftKings promo code, bet365 bonus code and FanDuel promo code all offer bonus bets after new users place a wager of $5 or more. DraftKings offers $200 in bonus bets if your first bet of at least $5 wins. The FanDuel promo code provides new users $300 in bonus bets if their first bet of $5 or more wins, while the bet365 bonus code offers $200 in bonus bets with a $5 wager, whether it wins or loses.
Both the Fanatics Sportsbook promo code and BetMGM bonus code provide bonus bets, but only if your first bet loses. Fanatics is offering new users the ability to get $100 in FanCash plus $100 No Sweat Bets in FanCash on every football Game Day until October. However, users in New York are limited to $25 in No Sweat Bets in FanCash. Using the BetMGM bonus code CBSSPORTS gives new users up to $1,500 back in bonus bets if their first bet loses. BetMGM users in West Virginia, New Jersey, Pennsylvania or Michigan can get a different promotion and claim $150 in bonus bets if you win your first bet of $10 or more.
The Caesars Sportsbook promo code is different than the others, providing profit boosts instead of bonus bets. After placing a wager of at least $1, you receive 20 100% profit boost tokens with the code CBS20X.
Betting on Week 5 of the 2025 NFL season
SportsLine’s computer model simulates every NFL game 10,000 times. Since its inception, it has generated a betting profit of well over $7,000 for $100 players on top-rated NFL picks. The model is on a sizzling 39-19 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.
Eagles -4.5 vs. Broncos
The Eagles kept their perfect record intact last week by securing a 31-25 victory on the road at Tampa Bay. Philadelphia ranks seventh in the NFL in scoring offense, averaging 27 points per game. The Eagles have won 13 consecutive games at home and are 4-1 against the spread in their last five meetings against an AFC West opponent. The Broncos, meanwhile, are 0-5 ATS in their past five games on the road. SportsLine’s model has Philadelphia covering the spread in 55% of simulations on Sunday.
Colts -6.5 vs. Raiders
Indianapolis is coming off its first loss of the season, but it was a one-score loss on the road against a strong Rams side. The Colts opened the season with consecutive victories over the Dolphins, Broncos and Titans. Quarterback Daniel Jones has been better than expected, passing for 1,078 yards and four touchdowns, while running back Jonathan Taylor has 414 rushing yards and three touchdowns. They should feast against a Las Vegas defense that has allowed 66 combined points in back-to-back losses to the Commanders and Bears. The model has Indianapolis winning by double digits, covering the spread 59% of the time.
Bills -8.5 vs. Patriots
Buffalo has raced out to a 4-0 start this season, so the crowd support and motivation will be high heading into this primetime divisional matchup. Bills quarterback Josh Allen has already thrown for 964 yards and seven touchdowns while rushing for 159 yards and three more scores. New England took care of business at home against Carolina in Week 4, but this will be its toughest opponent yet by far. The model does not think the Patriots stack up in this matchup, as the Bills are covering the large spread in 67% of simulations.
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