Week 4 of the NFL season closes with a Monday Night clash on Denver between the Cincinnati Bengals (2-1) and the Broncos (1-2).
Cincinnati continues its journey minus Joe Burrow who remains sidelined with yet another injury. Whispers that he is Ohio’s version of Andrew Luck are not far from the truth. Despite being without their All-Pro quarterback, the Bengals have an opportunity in the AFC North with the Ravens sitting at 1-3 and perhaps without league-MVP Lamar Jackson for a stretch. They will need to be better than last week when Jake Browning and co. were drilled 48-10 by Carson Wentz and the Vikings.
The Broncos need a win tonight to get back to .500 and pull to within one game of the Chargers who sit atop the AFC West. Bo Nix has taken a step back this season and Sean Payton’s offense has taken a hit as a result averaging less than 23 points per game. While the defense has been stout (64 points allowed through three games), the offense must be better. Their inability to sustain drives means a lopsided time of possession for their opponents which wears down Denver’s defense today and tomorrow.
Lets take a deeper dive into this week’s matchup between the Bengals and the Broncos at Empower Field.
NBC Sports has all the latest info and analysis you need, including how to tune in for kickoff, odds from DraftKings, player news and updates, and of course our predictions and best bets for the game from our staff of experts.
Game Details and How to watch the Bengals at the Broncos live Monday
Date: Monday, September 29, 2025
Time: 8:15PM EST
Site: Empower Field at Mile High
City: Denver, CO
Network/Streaming: ABC
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Game odds for the Bengals at the Broncos
The latest odds as of Monday courtesy of DraftKings:
Moneyline: Cincinnati Bengals (+380), Denver Broncos (-500)
Spread: Broncos -7.5
Total: 44.5 points
This game opened at Broncos -6.5 with the Total set at 44.5.
Be sure to check out DraftKings for all the latest game odds & player props for every matchup this week on the NFL schedule!
Quarterback Matchup for Cincinnati at Denver
Bengals Expected Starting QB: Jake Browning
Last Game: 9/21 at Minnesota – 19-27 (70.4%) 140yds, 1 TD, 2 INTs, Sacked 3 times, 1 carry for 3yds
Season Totals: 2GP, 40-59 (67.8%), 381yds, 3 TDs, 5 INTs, Sacked 4 times, 2 carries for 4yds
Broncos Expected Starting QB: Bo Nix
Last Game: 9/21 at LA Chargers – 14-25 (56%), 153yds, 1 TD, 0 INTs, Sacked 2 times, 8 carries for 33yds
Season Totals: 3GP, 61-95 (64.2%), 535yds, 5 TDs, 3 INTs, Sacked 3 times, 19 carries for 71yds
Cincinnati at Denver team stats, betting trends
The Bengals are 1-1 ATS with Jake Browning at QB this season
The Broncos are 2-0-1 ATS this season
Bo Nix is averaging 5.6 yards per attempt and Jake Browning is averaging 6.5 yards per attempt
Bengals Player Injuries
TE Noah Fant (concussion) has been ruled OUT of Monday’s game
DE Shemar Stewart (ankle) has been ruled OUT of Monday’s game
Broncos Player Injuries
WR Marvin Mims Jr. (hip) is listed as questionable for Monday’s Game
Rotoworld Bet Best Bets
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Drew Dinsick (@whale_capper): Cincinnati Bengals +7½ (-106)
Monday night stinker with the road Bengals catching more than a touchdown on the heels of a horrific performance against the Vikings. The Broncos defense should be reasonably strong in this contest and fuel a win, but the offense has been extremely underwhelming in Bo Nix’s sophomore season making it unlikely that they cover in the absence of a defensive special teams’ touchdown.
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Our model calculates projections around each moneyline, spread and over/under bet for every game on the NFL calendar based on data points like past performance, player matchups, stadium information and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Best bets our model is projecting for this week’s game between the Bengals and the Broncos:
Moneyline: NBC Sports Bet is recommending a play on the Cincinnati Bengals on the Moneyline.
Spread: NBC Sports Bet is leaning towards a play ATS on the Cincinnati Bengals at +7.
Total: NBC Sports Bet is recommending a play on the over on the Game Total of 44.0.
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