Another week, another round of must-see matchups across the NFL. One week after some stunning developments, like the Cleveland Browns upsetting the Green Bay Packers and the Philadelphia Eagles surviving the Los Angeles Rams with a walk-off field goal block, we’ve got another slate full of intriguing action in Week 4.
As we’ll do every week throughout the season, we’ve collected all of the best picks and gambling content from CBS Sports and SportsLine and put them in one place. That way, you can get picks against the spread from our CBS Sports experts as well as additional feature content for each game, including plays from top SportsLine experts and the SportsLine Projection Model, best bets from our staff, survivor picks and more. Ready? Let’s jump in.
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All NFL odds via SportsLine consensus odds. Which picks can you make with confidence in Week 4? And which Super Bowl contender goes down hard? Visit SportsLine, as its incredible model simulates every NFL game 10,000 times and is up well over $7,000 for $100 players on top-rated NFL picks since its inception.
Vikings at Steelers (Dublin, Ireland)
Sunday, 9:30 a.m. ET on NFL Network | Stream: Fubo (Try for free)
Steelers +2.5: “Carson Wentz got sacked three times in the first half against the Bengals, and now, he’ll be going up against a Steelers defense that racked up five sacks against the Patriots. Wentz probably would have been sacked more in Week 3, but the Vikings only threw the ball six times in the second half because they had such a huge lead. It’s much easier to play quarterback in the NFL when you have a 31-point lead. I’m guessing Minnesota won’t have a 31-point lead against the Steelers at any point, so this feels like a game where Pittsburgh’s defense will be able to tee off against Wentz.” — CBS Sports NFL writer John Breech on why he’s taking the Steelers to prevail in Ireland. Check out all his picks right here.
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Commanders at Falcons
Sunday, 1 p.m. ET on CBS | Stream on Paramount+
Commanders -1.5: The SportsLine Projection Model simulates every NFL game 10,000 times, providing expert recommendations for weekly bets. After analyzing every matchup on the Week 4 slate, the model zeroed in on a 29-20 prediction in favor of Washington, despite Jayden Daniels still nursing a knee injury, projecting the Commanders will comfortably cover in a game that goes Over 45.5 total points.
Saints at Bills
Sunday, 1 p.m. ET on CBS | Stream on Paramount+
Bills: SportsLine expert R.J. White is up more than 32 units on against-the-spread picks over the last eight years and even better with weekly top-five “best bets,” hitting 55% of his picks over the last 10 years in Las Vegas ATS contests. He thinks the Bills will be one of the two most popular selections for survivor pools as they host the rebuilding Saints, but what happens if Buffalo’s already been used? He’s got a full breakdown of alternative Week 4 picks for survivor formats right here at SportsLine.
Browns at Lions
Sunday, 1 p.m. ET on Fox | Stream: Fubo (Try for free)
Lions -9.5: The Browns may have upset the Packers in Week 3, but SportsLine’s NFL simulation model likes Detroit to cruise past Cleveland this time around. Up over $7,000 for $100 players on top-rated picks since its inception, the model identified the Lions as one piece of a longshot five-leg parlay that could return more than $6,000 for a $10 bettor, projecting Dan Campbell’s squad to cover the alternate spread of -14.5 against the Browns at home. Check out the full projection at SportsLine right here.
Panthers at Patriots
Sunday, 1 p.m. ET on Fox | Stream: Fubo (Try for free)
The Patriots may be nearly touchdown favorites against the Panthers while playing Week 4 at home, but the SportsLine simulation model is shying away from New England as a survivor-pool pick, one week after the Panthers stunned the Falcons with a 30-0 win and the Patriots fell to the Steelers, 21-14. The Patriots win this matchup 58% of the time, according SportsLine’s simulations, but that’s much less than several other teams in similar situations. Check out a full breakdown of Week 4 survivor options right here.
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Chargers at Giants
Sunday, 1 p.m. ET on CBS | Stream on Paramount+
Chargers -6.5: It’s Jaxson Dart time for the Giants, who are set to start their rookie quarterback for the remainder of the 2025 season. But will the Ole Miss product’s entry be enough to lift New York against a potential title contender in Los Angeles? Not so fast, says the SportsLine simulation model. One of the model’s strongest Week 4 picks involves the Bolts winning by more than a touchdown at MetLife Stadium, with simulations forecasting a Chargers win versus the spread more than 50% of the time.
Eagles at Buccaneers
Sunday, 1 p.m. ET on Fox | Stream: Fubo (Try for free)
Eagles -3.5: “Dating back to 2015, the Buccaneers have won six of their last seven against the Eagles. Both teams were shaky on Sunday but fortunate to come away with victories, although at least Philadelphia had the excuse of playing a good team in the Rams. With each being 3-0 and prohibitive division favorites, I wouldn’t be surprised to see this matchup again come January. But I’m going to trust the oddsmakers on this one, who came out with a Philly -3 line. I probably would’ve made the odds closer to even than a field goal considering the Eagles’ previous struggles in the Florida heat.” — ATS expert Eric Cohen, who is 35-13 picking games this year, offers his SportsLine projection for a 24-20 Philly win.
Titans at Texans
Sunday, 1 p.m. on CBS | Stream on Paramount+
Texans -7: Houston may have more than a few problems, looking to avoid an 0-4 start as C.J. Stroud and Co. try desperately to right the ship offensively. But this could be just the get-right game they need. The SportsLine simulation model scoured odds for every Week 4 game and locked in five best bets for the slate, offering top picks for a parlay that would produce a payout of around 24-1. One of those picks: The model is backing the Texans to cover against the rival Titans in more than 50% of simulations.
Colts at Rams
Sunday, 4:05 p.m. on Fox | Stream: Fubo (Try for free)
Colts +4.5: [Two of the Colts’] three wins have come against two of the worst teams in the league: the Dolphins and Titans. This week, they’ll be facing a Rams team that can stop the run. … The Colts defense has [also] been good this season, but it hasn’t been tested: They’ve faced Tua Tagovailoa (Week 1), Bo Nix (Week 2) and Cam Ward (Week 3). Not to knock those guys, but they’re not Matthew Stafford. When you have to go from facing Ward one week to facing Stafford in the next week, that’s like going from sparring against your neighbor in the gym to facing Mike Tyson in his prime.” — CBS Sports NFL writer John Breech on why he likes Indy to cover, but the Rams to win, Sunday’s Week 4 showdown.
Jaguars at 49ers
Sunday, 4:05 p.m. on Fox | Stream: Fubo (Try for free)
Jaguars +3: “The Jaguars have an awful history on the West Coast, but this is a chance to change that. The 49ers are banged up and might not have Brock Purdy again. Mac Jones, who is also banged up, was bad last week, and was bad for the Jaguars last year. So they know him well if he plays. Without Nick Bosa, the 49ers defense won’t be the same. The Jaguars will buck the trend and win in California.” — CBS Sports senior NFL columnist Pete Prisco on why he’s taking Jacksonville in a 29-26 upset.
Ravens at Chiefs
Sunday, 4:25 p.m. on CBS | Stream on Paramount+
Ravens -2.5: “This is a kitchen-sink game for both of these teams as they enter Week 4 looking to avoid a 1-3 start. While history tells us that Patrick Mahomes and Co. should have the upper hand in this matchup (5-1 against Lamar Jackson in his career), we’re siding with Baltimore. … Through three weeks, the Chiefs are averaging 20.0 points per game, 315.7 yards per game, and 5.2 yards per play. All of those are the lowest the franchise has produced since 2018 (Mahomes’ first season as the full-time starter). As for the Ravens, their 1-2 start is a bit different. While they’d like to win every game, falling to the Bills (Week 1) and Lions (Week 3) is understandable. The late-game turnovers are a concern, but Baltimore is simply the more talented and better put-together team at the moment.” — CBS Sports NFL writer Tyler Sullivan on why he’s betting on the Ravens bouncing back at Arrowhead. Find all his Week 4 picks right here.
Bears at Raiders
Sunday, 4:25 p.m. on CBS | Stream on Paramount+
Bears +1.5: “The Bears impressed in blowing out the Cowboys last week, while the Raiders looked bad in losing to the Commanders. I think Ben Johnson’s offense will continue to play well, but so will the Raiders and Geno Smith. This one will get loose, but the Bears take it.” — CBS Sports senior NFL columnist Pete Prisco on why he anticipates a high-scoring Chicago victory at Allegiant Stadium. Check out all of Prisco’s Week 4 projections, including this 33-30 win for the Bears, right here.
Packers at Cowboys
Sunday, 8:20 p.m. on NBC | Stream: Fubo (Try for free)
SportsLine expert R.J. White, a Fantasy and gambling editor for CBS Sports, returned more than $3,200 to $100 players on ATS picks from 2017-2024. He’s also especially in tune with Green Bay, going 77-32-22 (+3969) on his last 131 picks in games involving the Packers. So who does he like in this clash of NFC contenders, which brings Micah Parsons back to Arlington? We can tell you he’s leaning Under on the point total, but you’ll have to head over to SportsLine to get his expert projection for the final score.
Jets at Dolphins
Monday, 7:15 p.m. ET on ESPN | Stream: Fubo (Try for free)
Neither the Dolphins nor the Jets have yet to secure a victory this season. So who’s going to be the first to add a “W” under the prime-time lights? Emory Hunt is 18-9 (+805) in his last 27 picks involving the Jets, and he’s got a read on this one, which is the first of two Monday night games to close Week 4. You can find Hunt’s full breakdown of the matchup, including his ATS prediction, right here at SportsLine.
Bengals at Broncos
Monday, 8:15 p.m. ET on ABC | Stream: Fubo (Try for free)