Two teams with young, unproven quarterbacks take the field Sunday in Foxborough, MA when the Carolina Panthers (1-2) take the field against the New England Patriots (1-2).
Drake Maye was expected to take major strides in his second season under center for the Patriots. That has yet to happen as New England has failed to score more than 14 points in two of their three games. The Patriots lost four fumbles and Maye tossed an interception before ultimately losing this past Sunday to Pittsburgh, 21-14.
The Panthers, led by Bryce Young, take the field looking to build on their dominant 30-0 win over Atlanta last weekend. The Falcons outgained the Panthers but turned the rock over three times and Carolina’s defense suffocated Michael Penix Jr. and the Falcons, winning 30-0.
Fun Fact: It was the Panthers’ first shutout since their 20-0 win against the Detroit Lions on November 22, 2020.
Lets dive into this Week 4 matchup and see if we can find a sweat or two.
NBC Sports has all the latest info and analysis you need, including how to tune in for kickoff, odds from DraftKings, player news and updates, and of course our predictions and best bets for the game from our staff of experts.
Game Details and How to watch the Carolina Panthers at the New England Patriots live Sunday
Date: Sunday, September 28, 2025
Time: 1:00PM EST
Site: Gillette Stadium
City: Foxborough, MA
Network/Streaming: FOX
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Game odds for the Panthers at the Patriots
The latest odds as of Wednesday courtesy of DraftKings:
Moneyline: Carolina Panthers (+190), New England Patriots (-230)
Spread: Patriots -5.5
Total: 43.5 points
This game opened at Patriots -5.0 with the Game Total set at 43.5.
Be sure to check out DraftKings for all the latest game odds & player props for every matchup this week on the NFL schedule!
Quarterback Matchup for Carolina at New England
Panthers Expected Starting QB: Bryce Young
Last Game: 9/21 vs. Atlanta – 16-24 (66.7%), 121yds, 0 TDs, 0 INTs, Sacked 1 time, 2 carries for 8yds
Season: 3GP, 69-114 (60.5%), 603yds, 4 TDs, 3 INTs, Sacked 5 times, 9 carries for 50yds
Patriots Expected Starting QB: Drake Maye
Last Game: 9/21 vs. Pittsburgh – 28-37 (75.7%), 268yds, 2 TDs, 1 INT, Sacked 5 times, 7 carries for 45yds
Season: 3GP, 77-106 (72.6%), 785yds, 5 TDs, 2 INTs, Sacked 12 times, 21 carries for 87yds
Panthers at Patriots team stats, betting trends
The Panthers have lost 15 of their last 20 games
The Panthers have covered in 7 of their last 10 games
8 of the Panthers’ last 10 games (80%) have gone OVER the Total
Panthers Player Injuries
WR Xavier Legette (undisclosed) is listed as questionable for Sunday’s game
TE Ja’Tavion Sanders (undisclosed) is listed as doubtful for Sunday’s game
LB Patrick Jones II (undisclosed) is listed as questionable for Sunday’s game
DT Tershawn Wharton (undisclosed) is listed as questionable for Sunday’s game
G Robert Hunt (biceps) has been placed on IR and is OUT for Sunday’s game
C Austin Corbett (knee) has been placed on IR and is OUT for Sunday’s game
Patriots Player Injuries
CB Christian Gonzalez (undisclosed) is listed as questionable for Sunday’s game
Rotoworld Bet Best Bets
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Our model calculates projections around each moneyline, spread and over/under bet for every game on the NFL calendar based on data points like past performance, player matchups, stadium information and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Best bets our model is projecting for this week’s game between the Panthers and the Patriots:
Moneyline: NBC Sports Bet is staying away from a play on the Moneyline.
Spread: NBC Sports Bet is leaning towards a play ATS on the Carolina Panthers at +5.5.
Total: NBC Sports Bet is recommending a play on the over on the Game Total of 43.0.
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