The Week 4 NFL schedule features a compelling slate of matchups across the league. The Philadelphia Eagles (-3.5, 44) travel to Tampa Bay to face the Buccaneers in a battle of undefeated NFC teams, while the surprising Indianapolis Colts visit the Los Angeles Rams (-3.5, 48.5). In other games, the Cleveland Browns take on the Detroit Lions (-9.5, 44.5), the Jacksonville Jaguars face the San Francisco 49ers (-3, 47), and the Dallas Cowboys host the Green Bay Packers (-7, 47.5) on Sunday Night Football in Micah Parsons’ return to AT&T Stadium. With teams already jockeying for early-season positioning in the NFL standings, Week 4 promises to deliver exciting football action.
Effectively building NFL parlay picks can pay off big in your NFL betting strategy. NFL parlays come with a much greater risk than straight bets, but they also carry the potential of a much bigger reward. Before making any Week 4 NFL picks and parlays, you need to see the Week 4 NFL longshot parlay from SportsLine’s proven computer simulation model that pays out well over $8,000 on a $10 bet.
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The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model is on a sizzling 39-19 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.
Now that the simulation model has had a chance to digest the Week 4 NFL odds, it’s locked in its betting picks to form a 5-leg NFL parlay that could pay out well over $8,000 for a $10 bettor. You can only see the picks and full parlay by heading to SportsLine.
Top Week 4 NFL parlay picks
For Week 4, one of the model’s parlay picks is backing the Lions at the alternate line of -14.5 against the Browns, a bet that returns +162. The standard spread is Lions -9.5, but the model has spotted an opportunity to go much bigger here.
The Lions are projected to win 83% of the time, and the model’s winning margin is 15 points, leaving plenty of room to play alternate lines. The Lions bounced back from a tough loss in Week 1 with a blowout win over the Chicago Bears in Week 2. Meanwhile, the Browns enter this matchup at 1-2 with one of the league’s most inconsistent offenses.
The Detroit offense is powered by quarterback Jared Goff, who has thrown for 559 yards and six touchdowns with just one interception in 2025. The former No. 1 overall pick earned NFC Offensive Player of the Week honors in Week 2. Running back Jahmyr Gibbs has contributed 113 rushing yards and one touchdown on 21 carries, and has added 13 receptions for 41 yards. Wide receiver Amon-Ra St. Brown has recorded 160 receiving yards and three touchdowns on 13 receptions, including a standout performance in Week 2 with 115 yards and three touchdowns, earning the FedEx Air & Ground Player of the Week award.
Defensively, edge rusher Aidan Hutchinson has tallied one sack and two tackles through the first two games, but has consistently been a disruptive force in 2025. See the rest of the picks in the Week 4 NFL parlay here.
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How to make NFL parlay picks for a payout of well over $8k
The parlay also includes four additional picks from SportsLine’s computer model, including a first touchdown scorer prop bet that returns +850. You can only see the picks and the full parlay at SportsLine.