It is an AFC South showdown between two of the six remaining winless teams in the NFL when the Tennessee Titans (0-3) meet the Houston Texans (0-3) at NRG Stadium Sunday afternoon.
Fair to say the Titans were expected to struggle this season under rookie quarterback Cam Ward but the Texans were supposed to contend for another division title…and maybe make a deep playoff run. Houston may still turn things around and contend in the South, but they will need to fix the myriad of woes along their offensive line and get their third-year quarterback C.J. Stroud back on track in order to do so. The Texans have scored just 38 points this season, but the Titans may be the answer to their prayers having allowed 94 points through their dismal start.
Lets take a deeper dive into this Week 4 matchup between the Titans and the Texans.
NBC Sports has all the latest info and analysis you need, including how to tune in for kickoff, odds from DraftKings, player news and updates, and of course our predictions and best bets for the game from our staff of experts.
Game Details and How to watch the Titans at the Texans live Sunday
Date: Sunday, September 28, 2025
Time: 1:00PM EST
Site: NRG Stadium
City: Houston, TX
Network/Streaming: CBS
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Game odds for the Titans vs the Texans
The latest odds as of Tuesday courtesy of DraftKings:
Moneyline: Tennessee Titans (+280), Houston Texans (-355)
Spread: Texans -7 (-112)
Total: 39.5 points
This game opened at Texans -7.5 with the Total set at 40.0.
Be sure to check out DraftKings for all the latest game odds & player props for every matchup this week on the NFL schedule!
Quarterback Matchup for Tennessee at Houston
Titans Expected Starting QB: Cam Ward
Last Game: 9/21 vs. Indianapolis – 23-38 (60.5%), 219yds, 1 TD, 1 INT, Sacked 4 times, 3 carries for 12yds
Season: 3GP, 54-99 (54.5%), 506yds, 2 TDs, 1 INT, Sacked 15 times, 7 carries for 20yds
Texans Expected Starting QB: C.J. Stroud
Last Game: 9/21 at Jacksonville – 25-38 (65.8%), 204yds, 1 TD, 2 INTs, Sacked 2 times, 4 carries for 22yds
Season: 3GP, 57-89 (64%), 599yds, 2 TDs, 3 INTs, Sacked 8 times, 13 carries for 81yds
Tennessee Titans at Houston Texans team stats, betting trends
Only the Dolphins (97) have given up more points than the Titans (94) through three games this season
The Titans are 1-4 against the spread in their last 5 road games
The OVER is 7-3 in the Titans’ last 10 road games
Titans Player Injuries
RG Kevin Zeitler (undisclosed) is listed as questionable for Sunday’s game
RT JC Latham (undisclosed) is listed as questionable for Sunday’s game
WR Bryce Oliver (undisclosed) is listed as questionable for Sunday’s game
S Kevin Winston Jr. (undisclosed) is listed as questionable for Sunday’s game
DT T’Vondre Sweat (ankle) has been placed on IR and is out for Sunday’s game
Texans Player Injuries
CB Derek Stingley Jr. (oblique) is listed as questionable for Sunday’s game
S Jimmie Ward (foot) has been moved from the Commissioner Exempt List to the reserve/PUP list by the Texans
CB Jaylin Smith (hamstring) has been placed on IR
Rotoworld Bet Best Bets
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Our model calculates projections around each moneyline, spread and over/under bet for every game on the NFL calendar based on data points like past performance, player matchups, stadium information and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Best bets our model is projecting for this week’s game between the Titans and the Texans:
Moneyline: NBC Sports Bet is recommending a play on the Tennessee Titans on the Moneyline.
Spread: NBC Sports Bet is leaning towards a play ATS on the Tennessee Titans at +7.
Total: NBC Sports Bet is recommending a play on the over on the Game Total of 39.5.
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