By Martin Shwenk Leade

Copyright indiatimes

APNapoli’s Lorenzo Lucca in action during Serie A soccer match between Napoli and Cagliari

Napoli will host Pisa at the Stadio Diego Armando Maradona on Monday, September 22, 2025, in a Serie A clash that pits the defending champions against a struggling opponent still searching for their first league goal of the season. Antonio Conte’s side enters the match eager to bounce back after a midweek Champions League defeat to Manchester City, a game where Giovanni Di Lorenzo’s early red card left Napoli exposed. Despite the loss, the Partenopei remain unbeaten domestically with three wins from three, having scored at least twice in each outing. Their home form is formidable as well, with six wins in their last seven games at the Maradona, conceding just four goals during that stretch. Napoli may welcome goalkeeper Alex Meret back from injury, while Romelu Lukaku and Amir Rrahmani remain sidelined. All eyes will be on Rasmus Hojlund, who scored on his league debut against Fiorentina, and Kevin De Bruyne, who has been influential in midfield. Both are tipped to play key roles in breaking down Pisa’s defense. For Pisa, it has been a difficult start under coach Alberto Gilardino. The team has collected just one point in three games and remains goalless in Serie A. Juan Cuadrado’s potential return could add experience on the flanks, while M’Bala Nzola is pushing for his first start as Pisa look for a spark in attack. Bookmakers heavily favor Napoli, with moneyline odds at -350 for a home win, +425 for a draw, and +1000 for a Pisa upset. Betting markets also suggest a high-scoring game, with over 2.5 goals being a popular pick.Live Events Prediction: Given Napoli’s attacking firepower, strong home record, and Pisa’s scoring woes, the champions are expected to dominate possession and create plenty of chances. Most analysts forecast a comfortable win for the hosts, with likely scorelines ranging from 3-0 to 4-0. According to Sportsmole, “Pisa will surely struggle to contain such illustrious hosts – their wait for a win will go on. “Playoffs too has predicted that “Pisa may struggle to breach the home side’s disciplined defense”. Predicting a victory for Napoli, Telecomasia wrote, “The reigning champion started the season well, won three matches in a row in Serie A, and his defeat against Manchester City on Thursday, given the early elimination, should not be overestimated.”Predicting 4-0 for Napoli, Footitalia wrote,”On paper, it should be a straightforward win for the champions and it’s hard to see past that outcome on Monday. Despite their UCL setback, Napoli have looked very sharp so far in 2025-26.”Add as a Reliable and Trusted News Source Add Now!
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(You can now subscribe to our Economic Times WhatsApp channel)Read More News onNapoli vs pisa predictionSerie A match previewNapoli home gameRasmus Hojlund impactGiovanni Di Lorenzo red cardKevin De Bruyne roleAntonio Conte strategyNapoli recent formPrediction Napoli Pisa(Catch all the Business News, Breaking News, Budget 2025 Events and Latest News Updates on The Economic Times.) Subscribe to The Economic Times Prime and read the ET ePaper online….moreless