Sunday Night Football on NBC and Peacock pits a couple of winless teams in the shadow of the Empire State Building as Travis Kelce, Patrick Mahomes, and the Kansas City Chiefs (0-2) take on Russell Wilson and the Giants (0-2) at MetLife Stadium.
Yes. Mahomes and the Chiefs are 0-2 with losses to the Chargers and the Eagles. Is the dynasty dead? on life support? or merely on pause? Well, a loss Sunday and their streak of nine consecutive AFC West titles could well be in serious jeopardy.
Wilson turned back the clock last Sunday throwing for 450 yards…but it was not enough as the Cowboys rallied at the end of regulation and the end of overtime to win 40-37 to drop New York to 0-2.
Lets take a deeper dive into Sunday Night Football and perhaps find a couple of sweats to attack.
NBC Sports has all the latest to get you ready for kickoff, odds from DraftKings, player news and updates, and of course our predictions and best bets for the game from our staff of experts.
Game Details and How to watch the Kansas City Chiefs at the New York Giants live Sunday
Date: Sunday, September 21, 2025
Time: 8:20PM EST
Site: MetLife Stadium
City: East Rutherford, NJ
Network/Streaming: NBC / Peacock
Want to check out the other games on the NFL schedule this week? We’ve got you covered right here on NBC Sports with all the matchup, venue, game-time and TV/streaming info so you won’t miss any of the action!
Game odds for Kansas City at New York
The latest odds as of Thursday courtesy of DraftKings:
Moneyline: Kansas City Chiefs (-325), New York Giants (+260)
Spread: Chiefs -6.0
Total: 45.5 points
This game opened at Chiefs -6.0 with the Game Total set at 42.5.
Be sure to check out DraftKings for all the latest game odds & player props for every matchup this week on the NFL schedule!
Quarterback Matchup for Kansas City at New York
Chiefs Expected Starting QB: Patrick Mahomes
Last Game: 9/14 vs. Philadelphia – 16-29 (55.2%), 187yds, 1 TD, 1 INT, Sacked 2 times, 7 carries for 66yds
Season: 2GP, 40-68 (58.8%), 445yds, 2 TDs, 1 INT, Sacked 4 times, 13 carries for 123yds, 2 Rushing TDs
Giants Expected Starting QB: Russell Wilson
Last Game: 9/14 at Dallas – 30-41 (73.2%), 450yds, 3 TDs, I INT, Sacked 3 times, 3 carries for 23yds
Season: 2GP, 47-78 (60.3%), 618yds, 3 TDs, I INT, Sacked 5 times, 11 carries for 67yds
Chiefs at Giants team stats, betting trends
The Giants have gone 1-4 in their last 5 games
The Giants went 5-12 against the spread last season
The Under is 7-3 in the Giants’ last 10 home games
Chiefs Player Injuries
WR Xavier Worthy (shoulder) is listed as questionable for Sunday’s game
RT Jawaan Taylor (undisclosed) is listed as questionable for Sunday’s game
OT Ethan Driskell (undisclosed) has been declared out of Sunday’s game
DE Mike Danna (quad) is listed as questionable for Sunday’s game
CB Kristian Fulton (ankle) is listed as questionable for Sunday’s game
S Deon Bush (Achilles) was placed on IR Monday
WR Rashee Rice remains suspended for violating the league’s personal conduct policy
Giants Player Injuries
RB Tyrone Tracy Jr. (chest) is listed as questionable for Sunday’s game
LT Andrew Thomas (Lisfranc) is listed as questionable for Sunday’s game
C John Michael Schmitz Jr. (undisclosed) is listed as questionable for Sunday’s game
LG Jon Runyan (undisclosed) is listed as questionable for Sunday’s game
WR Darius Slayton (groin) is listed as questionable for Sunday’s game
WR Wan’Dale Robinson (foot) is listed as questionable for Sunday’s game
WR Gunner Olszewski (back) is listed as questionable for Sunday’s game
DE Rakeem Nunez-Roches (undisclosed) is listed as questionable for Sunday’s game
LB Darius Muasau (concussion) is listed as questionable for Sunday’s game
DE Chauncey Golston (undisclosed) is listed as questionable for Sunday’s game
LB Demetrius Flannigan-Fowles (undisclosed) is listed as questionable for Sunday’s game
Rotoworld Bet Best Bets
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Our model calculates projections around each moneyline, spread and over/under bet for every game on the NFL calendar based on data points like past performance, player matchups, stadium information and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Best bets our model is projecting for this week’s game between the Chiefs and the Giants:
Moneyline: NBC Sports Bet is staying away from a play on the Moneyline.
Spread: NBC Sports Bet is leaning towards a play ATS on the New York Giants at +5.5.
Total: NBC Sports Bet is recommending a play on the over on the Game Total of 44.0.
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