Saints vs. Seahawks prediction: Odds, expert picks, QB matchup, injury update, betting trends, and stats
The Seattle Seahawks (1-1) look to build on last week’s win over the Steelers as they welcome the winless New Orleans Saints (0-2) to Lumen Field Sunday afternoon.
After struggling to move the ball against the 49ers in Week 1, Sam Darnold and co. moved the ball up and down the field against the Steelers totaling 395 yards scoring twice in three trips inside the Red Zone. No doubt the expectation is Seattle will build on that performance at home against New Orleans.
The Saints have come up just short in each of their first two games suffering narrow losses to the Cardinals (20-13) and the 49ers (26-21). Spencer Rattler has been statistically solid under center throwing for 421 yards and three touchdowns without an interception.
One stat that may speak to the difference between these teams is quarterbacks’ average per attempt. Darnold is averaging 7.9 yards per attempt and Rattler 5.3. Doesn’t sound like much of a difference but how often does a possession come up 2-3 yards short of moving the chains?
Fun Fact: New Orleans has won each of the last four games against Seattle.
Lets take a deeper dive into this West Coast Week 3 matchup between the Saints and the Seahawks.
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Game Details and How to watch the New Orleans Saints at the Seattle Seahawks live Sunday
Date: Sunday, September 21, 2025
Time: 4:05PM EST
Site: Lumen Field
City: Seattle, WA
Network/Streaming: CBS
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Game odds for the Saints vs the Seahawks
The latest odds as of Sunday courtesy of DraftKings:
Moneyline: New Orleans Saints (+320), Seattle Seahawks (-410)
Spread: Seahawks -7.5
Total: 41.5 points
This game opened at Seahawks -6.5 with the Total set at 41.5.
Be sure to check out DraftKings for all the latest game odds & player props for every matchup this week on the NFL schedule!
Quarterback Matchup for New Orleans at Seattle
Saints Starting QB: Spencer Rattler
Last Game: 9/14 vs. San Francisco – 25-34 (73.5%), 207yds, 3 TDs, 0 INTs, Sacked 3 times, 4 carries for 14yds
Season: 2GP, 52-80 (65%), 421yds, 3 TDs, 0 INTs, Sacked 4 times, 8 carries for 43yds
Seahawks Starting QB: Sam Darnold
Last Game: 9\/14 at Pittsburgh – 22-33 (66.7%), 295yds, 2 TDs, 2 INTs, Sacked 2 times
Season: 2GP, 38-56 (67.9%), 445yds, 2 TDs, 2 INTs, Sacked 3 times, 2 carries for 14yds
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Saints at Seahawks team stats, betting trends
The Saints have won 4 straight games against the Seahawks
The Seahawks were 2-7 at home against the spread last season
The Under is 4-1 in the Saints’ last 5 games against NFC teams
Alvin Kamara has fumbled once this season and that is the Saints lone turnover of the season
Saints Player Injuries
LG Trevor Penning (toe) is listed as questionable for Sunday’s game
RT Taliese Fuaga (undisclosed) is listed as questionable for Sunday’s game
DE Chase Young (calf) is listed as questionable for Sunday’s game
WR Trey Palmer (hamstring) is listed as questionable for Sunday’s game
LG Dillon Radunz (undisclosed) is listed as questionable for Sunday’s game
Seahawks Player Injuries
WR Tory Horton (groin) is listed as questionable for Sunday’s game
RT Abraham Lucas (undisclosed) is listed as questionable for Sunday’s game
LB Ernest Jones IV (shoulder) is listed as questionable for Sunday’s game
S Julian Love (hamstring) is listed as questionable for Sunday’s game
CB Josh Jobe (knee) is listed as questionable for Sunday’s game
CB Devon Witherspoon (knee) is listed as questionable for Sunday’s game
S Nick Emmanwori (undisclosed) is listed as questionable for Sunday’s game
LB Derick Hall (undisclosed) is listed as questionable for Sunday’s game
DT Johnathan Hankins (back) has been declared out of Sunday’s game
RB Zach Charbonnet (foot) is listed as questionable for Sunday’s game
Rotoworld Bet Best Bets
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Our model calculates projections around each moneyline, spread and over/under bet for every game on the NFL calendar based on data points like past performance, player matchups, stadium information and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Best bets our model is projecting for this week’s game between the Saints and the Seahawks:
Moneyline: NBC Sports Bet is recommending a play on the New Orleans Saints on the Moneyline.
Spread: NBC Sports Bet is leaning towards a play ATS on the New Orleans Saints at +7.5.
Total: NBC Sports Bet is recommending a play on the over on the Game Total of 41.0.
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