The court heard that Isaacs stabbed his wife on the head, neck and body at their home in Craigleith Avenue.
Lady Ross said: “That was a place where she should have been safe. She died at the hands of a person with whom she should have been safe,” she said.
The judge said the victim – known as Naso – had three sons who had “experienced great loss.”
She said Naso had a responsible and valuable job as a carer and support worker.
During the trial, the court heard Isaacs believed Naso was having an affair with a colleague, Victor Unachukwa, which he denied.
Isaacs believed that, in the early hours of the morning of 1 January 2024, Naso had been texting Mr Unachukwa. He claimed this prompted him to arm himself with a knife.
During the attack Isaacs, who had been drinking, pushed his wife onto a bed and held her down.
Defence counsel Gareth Jones KC said Isaacs has a history of mental illness and was a “sad and pathetic” man who could not cope with his wife’s infidelity.
But advocate depute Ali Murray, for the Crown, maintained that the evidence showed that Isaacs was a murderer whose mental health was good at the time of the killing.