Week 3 in the NFL kicks off Thursday night with the Miami Dolphins (0-2) visiting Orchard Park for an AFC East tilt against the Buffalo Bills (2-0). Tua Tagovailoa and co. are in desperation mode having lost their first two games. They have scored just 35 points through two games while conceding 60. No question Head Coach Mike McDaniel’s seat is getting at least warm following this past Sunday’s loss at home to New England, 33-27. After a nail-biter in Week 1 against the Ravens, this past Sunday was a laugher for Josh Allen and the Bills as they routed the Jets, 30-10. The Bills seem to already be in firm control of the AFC East.
Lets take a deeper dive into this week’s matchup between the Miami Dolphins and the Buffalo Bills.
NBC Sports has all the latest info and analysis you need, including how to tune in for kickoff, odds from DraftKings, player news and updates, and of course our predictions and best bets for the game from our staff of experts.
Game Details and How to watch the Dolphins vs. Bills live Thursday
Date: Thursday, September 18, 2025
Time: 8:15PM EST
Site: Highmark Stadium
City: Orchard Park, NY
Network/Streaming: Amazon Prime Video
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Game odds for the Dolphins vs the Bills
The latest odds as of Thursday courtesy of DraftKings:
Moneyline: Miami Dolphins (+556), Buffalo Bills (-813)
Spread: Bills -12.5
Total: 49.0 points
This game opened Bills -10.5 with the Game Total set at 48.5.
Be sure to check out DraftKings for all the latest game odds & player props for every matchup this week on the NFL schedule!
Quarterback Matchup for Miami vs. Buffalo
Dolphins Starting QB: Tua Tagovailoa
Last Game: 9/14 vs. New England – 26-32 (81.3%), 315yds, 2 TD, 1 INT, Sacked 5 times
Season: 2GP, 40-55 (72.9%), 429yds, 3 TDs, 3 INTs, Sacked 8 times, 1 carry for 7yds
Bills Starting QB: Josh Allen
Last Game: 9/14 at Jets – 14-25 (56%), 148yds, 0 TDs, 0 INTs, Sacked 1 time, 6 carries for 59yds
Season: 2GP, 47-71 (66.2%), 542yds, 2 TDs, 0 INTs, Sacked 2 times, 20 carries for 89yds
Miami Dolphins at Buffalo Bills team stats, betting trends
The Bills have won 17 of their last 19 home games against AFC East opponents
The Bills are 4-1 against the spread in their last five games at home
The Dolphins’ last four road games at the Bills have gone over the expected total
Dolphins Player Injuries
WR Malik Washington (thumb) is listed as questionable for Thursday’s game
TE Darren Waller (hip) is listed as questionable for Thursday’s game
G Aaron Brewer (undisclosed) is listed as questionable for Thursday’s game
G Austin Jackson (toe) is on IR and is unavailable for Thursday’s game
LB Chop Robinson (undisclosed) is listed as questionable for Thursday’s game
DT Benito Jones (undisclosed) is listed as questionable for Thursday’s game
S Ifeatu Melifonwu (calf) is listed as questionable for Thursday’s game
CB Storm Duck (undisclosed) is listed as questionable for Thursday’s game
RB Jaylen Wright (knee) is listed as questionable for Thursday’s game
CB Ethan Bonner (undisclosed) is listed as questionable for Thursday’s game
Bills Player Injuries
DT Ed Oliver (ankle) is listed as questionable for Thursday’s game
LB Matt Milano (pectoral injury) is listed as questionable for Thursday’s game
CB Taron Johnson (undisclosed) is listed as questionable for Thursday’s game
CB Cam Lewis (undisclosed) is listed as questionable for Thursday’s game
LB Shaq Thompson (undisclosed) is listed as questionable for Thursday’s game
DT Larry Ogunjobi (suspended) is not eligible to play in Thursday’s game.
Rotoworld Bet Best Bets
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Our model calculates projections around each moneyline, spread and over/under bet for every game on the NFL calendar based on data points like past performance, player matchups, stadium information and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Best bets our model is projecting for this week’s game between the Dolphins and the Bills:
Moneyline: NBC Sports Bet is staying away from a play on the Moneyline.
Spread: NBC Sports Bet is leaning towards a play ATS on the Miami Dolphins at +12.5.
Total: NBC Sports Bet is recommending a play on the under on the Game Total of 49.0.
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