Money line favorites in the NFL had a rough Week 5, going 7-7 straight-up. Given the uncertainty, hitting on exact NFL score predictions could result in a huge payday of around 100-1. Can the Ravens (+7.5) avoid a 1-5 start with a win over the Rams at home, with Lamar Jackson’s availability in doubt? And will Kansas City (-2.5) avenge a tough Monday loss with a victory over 4-1 Detroit on Sunday Night Football? What should one make of the Monday Night Football two-game slate of Bills vs. Falcons (+4.5) and Bears vs. Commanders (-4.5), with the latter being the teams’ first meeting since Washington’s Hail Mary victory a year ago? Before making any Week 6 NFL picks, be sure to see the exact NFL score predictions from SportsLine expert Eric Cohen.
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A SportsLine expert and host, Cohen is evaluating the entire Week 6 NFL slate and delivers score predictions and logic for each matchup. He finished the 2024-25 season with a 190-95 record on straight-up NFL betting picks (69%) and was profitable for bettors. He’s 50-27-1 (65%) on straight-up picks so far this season. Anyone who followed Cohen’s NFL predictions has been profitable at their favorite sports betting sites and betting apps. You can only see Cohen’s Week 6 NFL exact score predictions at SportsLine.
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Top Week 6 NFL picks
After diving into all 15 games on the NFL Week 6 schedule, Cohen likes the Buccaneers (-3, 47.5) to win and cover at home against the 49ers at 4:25 p.m. ET on Sunday.
“You can parlay a Baker Mayfield MVP-Emeka Egbuka Rookie of the Year ticket at more than 20-1 odds. The way both are playing, I don’t hate it. The Buccaneers are in a class by themselves in the NFC South and will be hosting a playoff game come January. I can make an argument for a 13-4 season if all goes well for Tampa Bay. And many props to San Francisco for being 4-1 and winning last Thursday in LA, but this isn’t a good spot for them with still plenty of injury concerns to navigate on offense. Buccaneers 28, 49ers 21.” See his other Week 6 football score predictions at SportsLine.
How to make Week 6 NFL score predictions
In addition, Cohen is picking one team to blow out their opponents by three touchdowns. You can see who it is at SportsLine, and use promo code CHAMPIONSHIP to get your first month at SportsLine for just $1.