Giants at Saints prediction: Odds, expert picks, QB matchup, injury update, betting trends, and stats
After a successful debut as QB1 in New York, Rookie Jaxson Dart and the New York Giants (1-3) take the show on the road for the rookie signal caller’s first game away from MetLife Stadium Sunday when they take on Spencer Rattler and the Saints (0-4) in New Orleans.
The Giants and Dart upset the LA Chargers last weekend, 21-18. Dart scored a touchdown on the ground and threw for another score in the win. The news was not entirely good, though, as WR1, Malik Nabors, tore his knee and is lost for the season.
The Saints appear ready to challenge Tennessee for the worst record in the NFL this season. That said, New Orleans hung around in Buffalo for the first three quarters last weekend before ultimately losing 31-19 to the AFC East-leading Bills.
Lets take a deeper dive into this Week 4 matchup between the Giants and the Saints.
NBC Sports has all the latest info and analysis you need, including how to tune in for kickoff, odds from DraftKings, player news and updates, and of course our predictions and best bets for the game from our staff of experts.
Game Details and How to watch the Giants at the Saints live Sunday
Date: Sunday, October 5, 2025
Time: 1:00PM EST
Site: Caesars Superdome
City: New Orleans, LA
Network/Streaming: CBS
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Game odds for the Giants at the Saints
The latest odds as of Tuesday courtesy of DraftKings:
Moneyline: NY Giants (+105), New Orleans Saints (-125)
Spread: Saints -2.5
Total: 40.5 points
This game opened at Giants -2.0 with the Game Total set at 43.5.
Be sure to check out DraftKings for all the latest game odds & player props for every matchup this week on the NFL schedule!
Quarterback Matchup for New York at New Orleans
Giants Expected Starting QB: Jaxson Dart
Last Game: 9/28 vs. LA Chargers – 13-20, 111yds, 1 TD, 0 INTs, Sacked 5 times, 10 carries for 54yds
Season Totals: 3GP, 13-20, 111yds, 1 TD, 0 INTs, Sacked 5 times, 12 carries for 54yds
Saints Expected Starting QB: Spencer Rattler
Last Game: 9/28 at Buffalo – 18-27, 126yds, 1 TD, 0 INTs, Sacked 3 times, 6 carries for 49yds
Season: 4GP, 98-146, 765yds, 5 TDs, 1 INT, Sacked 9 times, 16 carries for 102yds
Giants at Saints team stats, betting trends
The Giants are 2-2 ATS and 1-3 to the OVER this season
The Saints are 3-1 to the OVER this season and are 1-3 ATS
6 of the Giants’ last 8 games against NFC teams have gone under the Total
Giants Player Injuries
QB Jaxson Dart (hamstring) is listed as questionable for Sunday’s game
S Jevon Holland (neck) is listed as questionable for Sunday’s game
K Graham Gano (groin) was placed on IR and will not play in this Sunday’s game
DE Chauncey Golston (ankle) is listed as questionable for Sunday’s game
WR Malik Nabors (knee) was placed on IR and has been declared OUT for Sunday’s game
DT Rakeem Nunez-Roches (undisclosed) is listed as questionable for Sunday’s game
Saints Player Injuries
RG Cesar Ruiz (ankle) has been declared OUT of Sunday’s game
LB Chase Young (calf) is listed as questionable for Sunday’s game
LG Dillon Radunz (toe) is listed as questionable for Sunday’s game
Rotoworld Bet Best Bets
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Our model calculates projections around each moneyline, spread and over/under bet for every game on the NFL calendar based on data points like past performance, player matchups, stadium information and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Best bets our model is projecting for this week’s game between the Giants and the Saints:
Moneyline: NBC Sports Bet is staying away from a play on the Moneyline.
Spread: NBC Sports Bet is leaning towards a play ATS on the New York Giants at +2.5.
Total: NBC Sports Bet is recommending a play on the over on the Game Total of 40.5.
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