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Vikings vs. Browns prediction: Odds, expert picks, QB matchup, injury update, betting trends, and stats

Vikings vs. Browns prediction: Odds, expert picks, QB matchup, injury update, betting trends, and stats

Its amazing how quickly a team’s season all of a sudden reaches a crossroads in the NFL. The Minnesota Vikings (2-2) seem to be at such a point this weekend as they play their second consecutive game in Europe (they were in Dublin, Ireland last weekend) when they take the field in London against the Cleveland Browns (1-3).
The Vikings are in this position following their 24-21 loss last weekend to the Steelers in their first of two consecutive games across the Pond. With games against the Eagles, Chargers, and Lions on the horizon, this game becomes paramount. Carson Wentz gets his third straight start in place of the injured J.J. McCarthy. The veteran is 1-1 since taking over as QB1.
The Browns were blasted last weekend by the aforementioned Lions in Motown, 34-10. Joe Flacco threw two more interceptions in the loss. He has thrown six already this season. The veteran’s QBR for the season sits at a less than desirable 27.0 which ranks 32nd in the NFL. For reference’s sake, Wentz ranks 29th with a QBR of 38.7.
With those numbers in mind, lets lessen our expectations for great play under center and take a deeper dive into this matchup.
NBC Sports has all the latest info and analysis you need, including how to tune in for kickoff, odds from DraftKings, player news and updates, and of course our predictions and best bets for the game from our staff of experts.
Game Details and How to watch the Vikings vs. the Browns live Sunday
Date: Sunday, October 5, 2025
Time: 9:30AM EST
Site: Tottenham Hotspur Stadium
City: London, England
Network/Streaming: NFL Network
Want to check out the other games on the NFL schedule this week? We’ve got you covered right here on NBC Sports with all the matchup, venue, game-time and TV/streaming info so you won’t miss any of the action!
Game odds for the Vikings vs. the Browns
The latest odds as of Sunday courtesy of DraftKings:
Moneyline: Minnesota Vikings (-198), Cleveland Browns (+164)
Spread: Vikings -4.5
Total: 36.5 points
This game opened at Vikings -5.0 with the Total set at 38.5.
Be sure to check out DraftKings for all the latest game odds & player props for every matchup this week on the NFL schedule!
Quarterback Matchup for Minnesota vs. Cleveland
Vikings Expected Starting QB: Carson Wentz
Last Game: 9/28 vs. Pittsburgh – 30-46, 350yds, 2 TDs, 2 INTs, Sacked 6 times, 2 carries for 12yds
Season: 2GP, 44-66, 523yds, 4 TDs, 2 INTs, Sacked 9 times, 4 carries for 16yds
Browns Expected Starting QB: Joe Flacco
Last Game: 9/28 at Detroit – 16-34, 184yds, 0 TDs, 2 INTs, Sacked 3 times, 3 carries for -1yds
Season: 4GP, 93-160, 815yds, 2 TDs, 6 INTs, Sacked 9 times, 6 carries for 13yds.
Vikings vs. Browns team stats, betting trends
The Vikings are 3-1 to the OVER this season
The Browns are 2-2 ATS this season
The Browns are 3-1 to the UNDER this season
The Vikings are 2-2 ATS this season
Vikings Player Injuries
QB J.J. McCarthy (ankle) has been declared OUT of Sunday’s game
LG Donovan Jackson (wrist) has been declared OUT of Sunday’s game
LB Andrew Van Ginkel (neck) has been declared OUT of Sunday’s game
TE Ben Yurosek (knee) is listed as questionable for Sunday’s game
OT Brian O’Neill (knee) is listed as questionable for Sunday’s game
C Ryan Kelly (concussion) is listed as questionable for Sunday’s game
Browns Player Injuries
WR Cedric Tillman (hamstring) is listed as questionable for Sunday’s game
WR DeAndre Carter (knee) has been placed on IR and has been declared OUT for Sunday’s game
LT Jack Conklin (elbow) is listed as questionable for Sunday’s game
DT Mike Hall Jr. (knee) is listed as questionable for Sunday’s game
Rotoworld Bet Best Bets
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Our model calculates projections around each moneyline, spread and over/under bet for every game on the NFL calendar based on data points like past performance, player matchups, stadium information and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Best bets our model is projecting for this week’s game between the Vikings and the Browns:
Moneyline: NBC Sports Bet is staying away from a play on the Moneyline.
Spread: NBC Sports Bet is leaning towards a play ATS on the Cleveland Browns at +3.5.
Total: NBC Sports Bet is recommending a play on the over on the Game Total of 36.5.
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